Natural Guanidineacetic Acid Raw materials Powder

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Guanidineacetic Acid Powder Usage and Synthesis.

Guanidinoacetic acid, also known as guanidineacetic acid and N-amidinoglycine, is an amino acid analog that is the only prerequisite for the synthesis of creatine in vertebrates.

Creatine is mainly found in muscle cells and is involved in the energy metabolism of the body, and it forms the phosphagen system together with phosphocreatine. When the body has an excess of ATP, phosphocreatine stores energy. When the body ATP supply is insufficient, phosphocreatine can generate ATP again.

This supplementation does not require the participation of oxygen and is much faster than the energy supplementation released directly from food oxidation, which can satisfy the energy needs of young animals under rapid muscle growth and emergency physiological state.

Uses of Guanidineacetic Acid.

Guanidinoacetic acid is a commonly used feed additive with several roles and effects.

Firstly, it can improve protein metabolism and amino acid balance of animals, thus reducing serum urea nitrogen level and reflecting the health condition of animals.

Secondly, guanidinoacetic acid can promote the fat metabolism of animals, increase the muscle fat content, form dense marbling, improve the structure of meat, and make the meat more flavorful and tasty.

In addition, it can protect the cellular structure and function of the liver and heart tissues of animals.

Adding appropriate amount of guanidinoacetic acid in feed can increase the growth rate of animals, improve feed utilization and reduce the feed-to-meat ratio.

In conclusion, guanidinoacetic acid is a safe, green feed additive without any side effects, which has a positive effect on the growth and health of animals.

Safety of Guanidineacetic Acid.

The administration of guanidinoacetic acid has no significant effect on the enzyme expression profile of the human liver and muscle, and the side effects associated with its administration are acceptable, such as weight gain, nausea, bloating, muscle cramps, and abdominal pain.

However, it is worth noting that guanidinoacetic acid consumption is able to increase serum homocysteine levels in addition to increasing serum creatinine levels and muscle creatine levels. This is due to the fact that guanidinoacetic acid is methylated to form creatine and at the same time is able to form S-adenosylhomocysteine, which is then hydrolyzed to cysteine and adenosine in the body.

Since homocysteine in serum is a clinically important indicator of atherosclerosis and cardiovascular disease, thus guanidinoacetic acid intake raises plasma homocysteine levels, which can be considered as a side effect of guanidinoacetic acid.

Product Method of Bulk Guanidineacetic Acid Powder.

Guanidine acetic acid was produced by reacting thiourea with ethyl bromide to form S-ethyl thiourea hydrobromide, and then reacting with glycine. Thiourea, ethidium bromide and anhydrous ethanol were mixed and warmed in a water bath for 3h to dissolve all the thiourea.

Then the ethanol and excess ethyl bromide were evaporated under reduced pressure, and the residue was crystallized and dried to obtain S-ethyl thiourea hydrobromide.

Sodium hydroxide solution was then added to the resulting S-ethylthiourea hydrobromide, and a hot solution of glycine and water was quickly added under cooling.

After crystallization, ether was added and left overnight, and the mixture was cooled in an ice bath for 2 h. The ether layer was separated. Filter by suction, wash with ice water, ethanol and ether in turn, and dry to obtain the finished product.

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