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In the medical field, L-glutamine is used to assist in cancer treatment, to reduce the side effects of chemotherapy and radiotherapy, and to improve the treatment of other diseases such as liver, kidney and metabolic disorders.
In the field of sports nutrition, L-glutamine has been extensively studied as a supplement, but its exact effects and dosage remain controversial. In the field of intestinal health, L-glutamine may enhance intestinal barrier function, reduce intestinal inflammation and promote intestinal mucosal repair.
Uses of L-Glutamine.
1. Used in biochemical research; in medicine for peptic ulcers, mental disorders, alcohol poisoning, and brain dysfunction in epilepsy patients; used to improve intellectual development in children.
2. Nutritional supplement and flavor enhancer. In medicine, used to treat digestive ulcers, alcohol poisoning, and to improve brain function.
3. This product is converted into glycosamines in the body, serving as a precursor for mucoprotein synthesis, promoting ulcer healing; primarily used as a medication for digestive tract ulcers. It can also be used as a brain function improver and to treat alcohol poisoning.
4. Used in biochemical research and as a bacterial culture medium.
Application of L-Glutamine.
1. Muscle growth is primarily achieved through the following aspects: providing the body with essential nitrogen, promoting protein synthesis within muscle cells; promoting muscle cell growth and differentiation through cell volume expansion; and stimulating the secretion of growth hormone, insulin, and testosterone, putting the body in an anabolic state.
2. Glutamine has a potent effect.
It increases strength and improves endurance. During exercise, the increase in acidic metabolic products acidifies body fluids. Glutamine has the potential to produce bases, thus reducing the decrease in exercise capacity or fatigue caused by acidic substances to some extent.
3. It is an important fuel for the immune system, enhancing its function.
Glutamine plays a crucial role in immunomodulation; it is essential for lymphocyte secretion, proliferation, and functional maintenance. As a precursor and primary energy source for nucleic acid biosynthesis, glutamine promotes the mitosis and differentiation of lymphocytes and macrophages, increasing the production of cytokines such as TNF and IL-1, and the synthesis of phospholipid mRNA. Providing exogenous glutamine can significantly increase the total number of lymphocytes, T lymphocytes, and the circulating CD4/CD8 ratio in critically ill patients, enhancing the body's immune function.
4. Participates in the synthesis of glutathione (an important antioxidant).
5. A basic energy source for gastrointestinal luminal cells.
Glutamine is an essential nutrient for the metabolism of intestinal mucosal cells and plays a vital role in maintaining the integrity of the intestinal mucosal epithelial structure. Especially under severe stress conditions such as trauma, infection, and fatigue, glutamine in intestinal mucosal epithelial cells is rapidly depleted. When the intestine lacks stimulation from food, digestive juices, or glutamine, the intestinal mucosa atrophies, villi become sparse, shorter, or even detach, crypts become shallower, intestinal mucosal permeability increases, and intestinal immune function is impaired. Clinical practice has proven that parenteral glutamine provision can effectively prevent intestinal mucosal atrophy, maintain normal intestinal mucosal weight, structure, and protein content, enhance intestinal cell activity, improve intestinal immune function, and reduce the translocation of intestinal bacteria and endotoxins.
7. Improves brain function.
8. Enhances the body's antioxidant capacity.
Glutamine supplementation can enhance the body's antioxidant capacity by maintaining and increasing the GSH reserves in tissue cells, stabilizing cell membranes and protein structure, protecting the function of vital organs such as the liver, lungs, and intestines, as well as immune cells, and maintaining the normal function of the kidneys, pancreas, gallbladder, and liver.
9. Glutamine-fortified nutritional support can improve metabolism, nitrogen balance, promote protein synthesis, and increase the total number of lymphocytes.
Improves metabolic status: Glutamine plays a positive role in promoting protein metabolism.
10. Glutamine can maintain intestinal permeability in patients with severe pancreatitis, reduce the occurrence of intestinal bacterial translocation, inhibit the release of inflammatory mediators, reduce the degree of stress response, and shorten hospital stay.
Product Method of L-Glutamine.
L-glutamic acid is obtained via γ-hydrazide, usually by amidating L-glutamic acid-γ-methyl ester in the presence of carbon disulfide.
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