HRK Supply D-Glucosamine sulfate raw Materials powder

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D-Glucosamine sulfate Powder Usage and Synthesis.

Glucosamine, a natural amino monosaccharide derivative, is an essential component of proteoglycan synthesis in cartilage matrix. The proteoglycan can make articular cartilage have the function of absorbing impact force by inhibiting the stretching force of collagen fibers. In the early stage of joint degenerative disease, the biosynthesis of glucosans is increased. In the later stages of the disease, the opposite is true.

As a result, the elasticity of the cartilage is gradually weakened and the symptoms of arthritis gradually appear. Amino monosaccharides can stimulate chondrocytes to produce glycoproteins with normal polymer structure, inhibit some enzymes (such as collagenase) that can damage articular cartilage, prevent corticosteroids and some non-steroidal anti-inflammatory drugs from damaging chondrocytes, and reduce the release of endotoxin factors that damage cells. Exogenous glucosamine supplementation may play a beneficial role in the development of arthritis.

In vitro tests, if glucosamine is supplemented, the cartilaginous polymorphous cells can synthesize more aggregated glucosans. In animal models of arthritis, glucosamine also has an antioxidant effect, inhibiting the production of superoxide free radicals that damage cells. Through the above pathways, glucosamine exerts a direct anti-inflammatory effect that can relieve the painful symptoms of osteoarthritis, improve joint function, and can stop the progression of osteoarthritis disease.

Uses of D-Glucosamine sulfate.

Glucosamine sulfate can be used to prevent and treat various types of osteoarthritis, such as knee, hip, spine, shoulder, hand, wrist and ankle and systemic osteoarthritis.

In vitro study of D-Glucosamine sulfate.

Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity.

Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins.

Glucosamine sulfate significantly decreases renal expression of alpha -smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells.

Product method of Bulk D-Glucosamine sulfate Powder.

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