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By activating PGC-1α (a key protein that regulates mitochondrial biogenesis), it enhances cellular energy metabolism and may be used in research on anti-tumor or metabolic diseases (such as diabetes and muscle atrophy).
Some studies have shown that it may inhibit glycolysis in cancer cells ("Warburg effect"), forcing cancer cells to rely on mitochondrial function, thereby increasing sensitivity to chemotherapy.
Application of SLU PP 332 capsule.
1. Anti-tumor research
Combined chemotherapy/radiotherapy: In cell experiments, PP-332 may enhance the sensitivity of cancer cells to traditional treatments by regulating mitochondrial metabolism.
Overcoming drug resistance: Explore its effects on drug-resistant tumors (such as triple-negative breast cancer and non-small cell lung cancer).
2. Metabolic disease intervention
Type 2 diabetes: Animal studies have shown that PP-332 may improve insulin resistance and glucose metabolism.
Muscular dystrophy: Potential use for sarcopenia or Duchenne muscular dystrophy (maintaining muscle function by activating PGC-1α).
3. Sports science and physical fitness enhancement (theoretical speculation)
Simulating exercise effects: PGC-1α activation may increase mitochondrial energy production, but there is no clinical evidence to support its safety and effectiveness.
4. Anti-aging and neurodegenerative diseases (under exploration)
Very few studies have speculated on its potential neuroprotective effects on Alzheimer's disease and Parkinson's disease, but the data are extremely limited.
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Function of SLU PP 332 capsule.
1. Regulating mitochondrial metabolism & anti-tumor potential
Target: Activate PGC-1α (peroxisome proliferator-activated receptor gamma coactivator 1α), promote mitochondrial biogenesis and energy metabolism.
Potential effects:
Inhibit cancer cell growth: By forcing cancer cells to switch from glycolysis (Warburg effect) to mitochondrial respiration, their sensitivity to chemotherapy or radiotherapy may be enhanced.
Overcoming drug resistance: Some studies suggest that PP-332 may help reverse tumor resistance to traditional treatments (such as breast cancer and lung cancer models).
2. Metabolic disease intervention
Muscle and energy metabolism:
In animal experiments, PP-332 showed the potential to improve muscle endurance and metabolic function, similar to exercise mimics (such as the "exercise pill" concept).
Potential applications in muscular dystrophy, type 2 diabetes or obesity (by enhancing the ability of mitochondria to burn fat).
3. Anti-aging research
Because PGC-1α is associated with aging-related mitochondrial function decline, PP-332 is explored as a candidate molecule for delaying aging (no human evidence yet).
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