Desloratadine Powder CAS 100643-71-8 Raw Material

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Desloratadine Powder Usage and Synthesis.

Desloratadine (desloratadine) is the active metabolite of loratadine (loratadine) in vivo from the deformylation of ethyl formate.

Desloratadine Powder is a new 3rd generation antihistamine with potent anti-allergic action, rapid onset of action and long-lasting efficacy. Desloratadine Raw Material has affinity and selectivity for peripheral H1 receptors. 

Desloratadine Raw Material has affinity and selectivity for terminal H1 receptors, Desloratadine Raw Material is a new drug for the treatment of Desloratadine Raw Material is a new drug for the treatment of seasonal allergic rhinitis and chronic urticaria.

Desloratadine Powder is 50 to 200 times more potent than loratadine, fexofenadine, or cetirizine in in vitro models of human H1 receptor expression. It is 50-200 times more active than loratadine, fexofenadine, or cetirizine in in vitro models of human H1 receptor expression. It is 50-200 times more active than loratadine, fexofenadine or cetirizine, and is safe and effective, well tolerated by patients, with a half-life of 21-24h.

Uses and functions of Desloratadine Powder.

It has been used in the treatment of allergic diseases, including chronic idiopathic urticaria, perennial allergic rhinitis and other allergic diseases. In addition, it can also relieve the symptoms of cold urticaria.

• 1.Treatment of Allergic Rhinitis (AR) With the increased knowledge of the specific mediators that play a unique role in early and late allergic reactions, such as histamine, prostaglandin D2, leukotriene C4, IL-3, IL-8, ICAM-1, etc., a number of therapeutic routes targeting the allergic cascade have emerged. Desloratadine can effectively inhibit the release of inflammatory mediators at multiple sites in this cascade, thus preventing various symptoms of AR such as nasal congestion, etc.).

• 2.Treatment of chronic idiopathic urticaria (CIU) Clinical trials have shown that desloratadine can reduce the frequency of itching by 75% in CIU patients within 6h. The clinical trials of Desloratadine on CIU led by the Department of Dermatology of the First Affiliated Hospital of Nanjing Medical University and Huashan Hospital of Fudan University showed that after the first dose of Desloratadine was applied for 2 and 4 weeks, the scores of the patients on the basis of the maximum size of the windsock, the number of windsocks, itching and the total symptom scores were increased by up to 80%, which indicated that Desloratadine had a very good therapeutic efficacy on CIU.

Pharmacological Effects of Desloratadine Powder.

• 1. Desloratadine has strong anti-allergic effect and binds specifically to H1 receptor with high selectivity, which has the strongest binding ability to H1 receptor among the currently known antihistamines and has significant anti-H1 receptor effect.
• It is 4 times more potent than loratadine in inhibiting histamine-induced foot swelling in mice. Desloratadine inhibited the release of inflammatory cytokines from stimulated human mast cells and basophils at the nanomolar level, including IL-3, IL-6, TNF-α, GM-CSF, etc. This inhibition was stronger than that of dexamethasone and cetirizine.

• 2.Fast onset of action, long-lasting effectDicloretadine itself is active, well absorbed, the onset of action time is less than 30min.
• After oral about 3h to reach the maximum blood concentration, a single dose of the drug Cmax for 3.98ng-mL-1, clearance rate of 114 ~ 201L-h-1. An allergic rhinitis patients as the object of clinical onset of action time study proved that dicloretadine than the existing antihistamines are faster than the onset of action of the average onset of action time of 28.45min, while the loratadine and imipramine 1h, cetirizine for 2h. The average onset of action is 28.45min, compared with 1h for loratadine, 1h for imipramine and 2h for cetirizine.

Respiratory system and anti-allergic drugs

Production method of Desloratadine Powder.

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