Anti-inflammatory and analgesic Flunixin Meglumine Powder

Related Attributes

Product details

Flunixin Meglumine Powder Usage and Synthesis.

Flunixin Glucosamine, belongs to the veterinary class of anti-inflammatory analgesics, with antipyretic, anti-inflammatory and analgesic effects, alone or in combination with antibiotics can significantly improve clinical symptoms, and can enhance the activity of antibiotics.

It is commonly used in veterinary clinics to relieve visceral colic, pain caused by muscular and skeletal disorders and anti-inflammatory in horses; control of acute inflammation caused by various disease infections in cattle, such as hoof lobe inflammation, arthritis, etc. In addition, it can also be used in the adjuvant treatment of mastitis, uterine inflammation and lactation-free syndrome in sows.

Veterinary medicine for the relief of inflammation and pain caused by muscular anomalies, relief of visceral colic in horses, treatment of diarrhoea, trembling, colitis, respiratory and other systemic diseases in foals.

Uses and functions of Flunixin Meglumine.

Veterinary class anti-inflammatory and analgesic, the drug is used in horses to relieve inflammation and pain caused by muscular anomalies, to relieve visceral colic in horses, to treat diarrhoea, trembling, colitis, respiratory disorders, eye surgery in foals.

Used in cattle, to treat respiratory diseases, mastitis caused by endotoxin. Used in dogs to treat arthritis

The drug is used in horses to relieve inflammation and pain caused by muscle anomalies, to relieve visceral colic in horses, to treat diarrhoea, trembling, colitis, respiratory diseases, eye surgery in foals. Used in cattle to treat respiratory disorders, endotoxin-induced mastitis.

Used in dogs to treat arthritis, fever, diarrhoea, tremors, eye infections etc. Used for pigs, treatment of diarrhoea, etc.

Preparation of Flunixin Meglumine.

(1) 2-chloronicotinic acid and 2-methyl-3-trifluoromethylaniline are added to an aqueous sodium hydroxide solution and stirred, the molar ratio of said 2-chloronicotinic acid to 2-methyl-3-trifluoromethylaniline is 3:1; the molar ratio of said 2-chloronicotinic acid to sodium hydroxide used in the preparation of an aqueous sodium hydroxide solution is 1:2; ethylene glycol as well as a chained poly(ethylene glycol) dialkyl ether and a catalyst A are added, the amount of said chained The amount of polyethylene glycol dialkyl ether is 3% of the cast mass of 2-chloronicotinic acid; said Catalyst A is p-toluenesulfonic acid and copper oxide, and the molar ratio of said p-toluenesulfonic acid and copper oxide is 3: 1; control the temperature at 45 ℃, and after the reaction for 0.6 hours, adjust the PH of solution, and then stirring and static delamination, and then stirring and filtration, and then washing filtering, and then drying to get flunixin;

(2) The reaction of flunixin and N-methylglucosamine in isopropanol obtained in step (1), the molar ratio of said flunixin and N-methylglucosamine is 2:1; the volume ratio of the mass of flunixin to isopropanol is 1:11; and at the same time, maltodextrin is added; the molar ratio of said maltodextrin and 2-methyl-3-trifluoromethyl The molar ratio of said maltodextrin and 2-methyl-3-trifluoromethylaniline is 1:2.5; heating reflux, filtration, cooling, stirring crystallisation, wait until the temperature of the system is reduced to below 25 ° C and continue stirring, the crystals are pumped and filtered and washed by isopropanol to obtain flunixin glucosamine.

Pharmacological Effect of Bulk Flunixin Meglumine Powder.

Flunixin glucosamine is a cyclooxygenase inhibitor, through inhibiting cyclooxygenase in the reaction chain of arachidonic acid, reducing the production of inflammatory mediators such as prostaglandins and thromboxanes, maintaining normal blood pressure, reducing the damage to vascular endothelial cells, maintaining normal blood volume and other pathways, and preventing the increase of endobronchial exudate caused by E. coli endotoxin in respiratory diseases, the aggregation of neutrophils and albumin in the exudate and other pathways, effectively relieving fever and pain. The drug is effective in relieving fever, inflammation and pain in the body.

The drug acts quickly and usually reduces pain within 15 minutes. It is more effective than analgesics, pethidine and codeine, and is four times more effective than prednisone in the treatment of lameness and joint swelling in horses.

Why choose us?

HRK Factory

About Shipping