Nitrofurantoin Raw Materials powder Nitrofurantoin

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Furantoin is used for acute simple lower urinary tract infection caused by Escherichia coli, Enterococcus, Staphylococcus, Klebsiella, Enterobacter and other bacteria that are sensitive to it. It can also be used to prevent urinary tract infections.

Uses of Nitrofurantoin powder.

The product is an excellent antibacterial drug, after oral absorption is rapid and complete, excretion is also faster, the amount of excretion in the urine can reach 40-50%, often used to treat a variety of sensitive bacteria caused by urinary tract infection, acute urinary tract infection caused by Escherichia coli, the effect is better. It is an excellent antibacterial drug, with a wide antibacterial spectrum, suitable for urinary tract infections, such as pyelonephritis, pyelitis and cystitis.

Pharmacological action of Nitrofurantoin powder.

This product has a wide antibacterial spectrum, and its mechanism of action is to interfere with the oxidoreductase of bacteria and block the normal metabolism of bacteria. It has good antibacterial effect on staphylococcus, enterococcus, Escherichia coli, Neisseria (gonococcus, etc.), Subtilis, Shigella, salmonella, etc. It has weak effect on Proteus, Klebsiella, Enterobacter and Serratia. Not effective against Pseudomonas aeruginosa. Generally speaking, the microorganism is not easy to resist the drug, and it can still be effective after stopping the drug. But drug-resistant strains have increased in recent years. When necessary, it can be combined with other drugs (such as TMP) to improve efficacy.

Product Method of Bulk Nitrofurantoin powder.

Acetone semicarbazone is produced by condensation of hydrazine hydrate and urea, and then condensation with acetone. Then, acetone hydantoin was synthesized with ethyl chloroacetate ring, which was hydrolyzed and condensed with 5-nitrofurfural diacetate to produce furantoin.

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