Veterinary Medicine Trimethoprim Powder CAS 738-70-5 Raw Materials

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Trimethoprim Powder Usage and Synthesis.

methoxybenzylaminopyrimidine, antimicrobial synergist, methoxybenzylaminopyrimidine, methoxybenzylaminopyrimidine, trimethoprim, trimethoprimidine, trimethoprimidine Trimethoprimidine, antimicrobial synergist, methoxybenzylaminopyrimidine 

Veterinary Medicine Trimethoprim is a white or off-white crystal powder at room temperature, odorless, bitter taste, slightly soluble in chloroform, slightly soluble in ethanol or ethylene glycol, slightly soluble in ethylene glycol, slightly soluble in ethylene glycol, slightly soluble in ethylene glycol, slightly soluble in ethylene glycol, slightly soluble in ethylene glycol. Odorless, bitter taste, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water. Odorless, bitter taste, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, soluble in glacial acetic acid.

The antimicrobial spectrum is similar to sulfonamides, but the antimicrobial effect is stronger, methotrexate is a bacterial dihydrofolate reductase The antimicrobial spectrum is similar to sulfonamides, but the antimicrobial effect is stronger, methotrexate is a bacterial dihydrofolate reductase inhibitor, Trimethoprim Raw Materials antimicrobial principle of action is to interfere with the bacterial metabolism of folic acid.

Uses and functions of Trimethoprim Powder.

The antimicrobial spectrum is similar to that of sulfonamides, but the antimicrobial effect is stronger. It is effective against Escherichia coli, Proteus mirabilis, Pneumococcus pneumoniae, Staphylococcus putrefaciens, and a variety of Gram-positive and -negative bacteria, but it is ineffective against Pseudomonas aeruginosa infections, and the lowest inhibitory concentration is often lower than 10 mg/L. The use of this product alone may easily lead to bacterial resistance, so it is generally not used alone, and it is mainly used in the treatment of urinary tract infections as a combination with sulfonamides, Intestinal infections, respiratory infections, bacillary dysentery, enteritis, typhoid fever, meningitis, otitis media, otitis media, sepsis and soft tissue infections.

The efficacy of typhoid fever and paratyphoid fever is not lower than ampicillin, and it can also be used in the prevention and treatment of drug-resistant falciparum malaria in combination with long-acting sulfonamides.

New oral broad-spectrum antibacterial drugs. The antimicrobial spectrum is similar to sulfonamides but more potent, effective against a variety of Gram-positive and negative bacteria. Because of the bacteria will be easy to produce drug resistance to this product, so it is not suitable for use as antibacterial drugs alone. Combined with sulfonamides, methotrexate can enhance the antibacterial effect several times to dozens of times. This product is mainly used as a synergist of sulfonamides.

It is usually used in the ratio of 1:5. It can also be used as veterinary medicine for the treatment of septicemia caused by avian coliform liver bacteria, chicken dysentery, avian typhoid, cholera, respiratory system secondary bacterial infections. It can also be used in the treatment of coccidiosis.

Preferred as an antimicrobial, prokaryotic enzyme-selective inhibitor of dihydrofolate reductase; specific dosage form inhibitor widely used in the study of dihydrofolate reductase; inhibits the synthesis of tetrahydrofolate through prokaryotic specific dihydrofolate reductase (DHFR).

Pharmacological Effects of Trimethoprim Powder.

Trimethoprim is an inhibitor of bacterial dihydrofolate reductase, and its antibacterial effect is to interfere with bacterial folate metabolism. Inhibitory spectrum: Streptococcus spp. including Streptococcus pneumoniae, Escherichia coli, Salmonella spp., Proteus mirabilis, Pneumocystis pneumoniae, Dysentery bacillus, Typhoid fever bacillus, Whooping cough bacillus, etc. are sensitive to Trimethoprim. In addition, methicillin also has a certain effect on Plasmodium and certain fungi, such as Nucella, Histoplasma, yeast. In vitro, it has good antibacterial activity against Vibrio cholerae and Chlamydia trachomatis. Trimethoprim has no antibacterial effect on Pseudomonas aeruginosa, meningococcus and alkali producing bacteria.

Production method of Trimethoprim Powder.

Trimethoxybenzaldehyde as raw material, first condensed with methoxypropionitrile to form 3'4'5'-trimethoxy-2-cyano-3-methoxypropene, and then cyclized with guanidine nitrate in methanol/sodium methanolate to obtain.

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