Veterinary Medicine Diclofenac Sodium Powder CAS 15307-79-6 Raw Materials

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Diclofenac Sodium Powder Usage and Synthesis.

Diclofenac Sodium Powder is a white crystalline powder, with trade names such as Futenarin, Diclofenac, Diclofenac, Diclofenac Sodium Raw Materials, Diclofenac Sodium Raw Materials is a non-steroidal anti-inflammatory drug (NSAID) derived from phenylacetic acid, which is mainly used for the treatment of osteoarthritis, rheumatoid arthritis, polymyositis, and dermatomyositis, spondyloarthropathies, ankylosing spondylitis and other conditions requiring acute pain relief. 

Veterinary Medicine Diclofenac Sodium is a potent antipyretic, analgesic and anti-inflammatory drug.

The anti-inflammatory effect of Diclofenac Sodium is 2-2.5 times stronger than that of indomethacin and 26-50 times stronger than that of acetylsalicylic acid. It is suitable for rheumatoid arthritis, osteoarthritis, post-surgical pain relief and fever caused by various reasons.

Uses and functions of Diclofenac Sodium Powder.

Diclofenac Sodium is used as an anti-inflammatory and analgesic, mainly for the treatment of osteoarthritis, rheumatoid arthritis, polymyositis, dermatomyositis, spondyloarthropathies, ankylosing spondylitis, gout, as well as for the treatment of migraines, dental pain, gallstones and kidney stones that require acute pain relief.

Diclofenac sodium is a potent antipyretic, analgesic and anti-inflammatory drug. Its anti-inflammatory effect is 2-2.5 times stronger than that of indomethacin and 26-50 times stronger than that of acetylsalicylic acid. It is indicated for rheumatoid arthritis, osteoarthrosis, post-surgical pain relief and fever of various causes.

Standard NSAID as well as cyclooxygenase (COX) inhibitor; used as a selective substrate for CYP2C9.

Pharmacological Effects of Diclofenac Sodium Powder.

Production method of Diclofenac Sodium Powder.

• Synthesis of 2,6-dichlorodiphenylamine: 2,6-dichlorophenol and aniline were used as raw materials to obtain 2,6-dichlorodiphenylamine by acylation, condensation, Chapman rearrangement and hydrolysis.
• The three-step reactions of acylation, condensation and rearrangement, except for the recovery of solvents (toluene for acylation, and DMF for condensation and rearrangement), were carried out in a "one-pot" manner, i.e., they were completed in the same reactor without the need to separate the step-by-step process.

• The reaction is reproducible.
• Synthesis of diclofenac sodium: 2,6-dichlorodiphenylamine and chloroacetyl chloride were used as the main raw materials, and 1-(2,6-dichlorophenyl)dihydroindol-2-one was obtained by acylation and intramolecular Foucault alkylation, and finally, the product, diclofenac sodium, was obtained by alkaline hydrolysis of ring-opening.

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