Veterinary Medicine Paracetamol / Acetaminophen Powder CAS 103-90-2 Raw Materials

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Paracetamol / Acetaminophen Powder Usage and Synthesis.

　　Paracetamol Powder Acetaminophen is a phenolic organic substance used for fever caused by the common cold or influenza.Acetaminophen Powder is also used for the relief of mild to moderate pains such as headaches, joint pain, migraines, toothaches, muscular pain, neuralgia, and menstrual cramps.

　　Veterinary Medicine Paracetamol Organic synthesis intermediate, stabilizer of hydrogen peroxide, photographic chemical, Veterinary Medicine Paracetamol Non-anti-inflammatory antipyretic and analgesic. Used as an antipyretic, analgesic, antirheumatic agent.

Uses and functions of Paracetamol / Acetaminophen Powder.

　　Acetaminophen Powder is mainly used for cold-induced fever, headache and relief of mild and moderate pain, such as arthralgia, muscular pain, neuralgia, migraine, dysmenorrhea, cancer pain and post-surgical analgesia, etc.; it can also be used for patients who are allergic to,

　　intolerant of, or unfit for aspirin: such as chickenpox, hemophilia, and other bleeding disorders (including patients who are under the application of It can also be used for patients who are allergic to aspirin, intolerant or not suitable for aspirin application: such as chicken pox, hemophilia and other bleeding disease patients (including the application of anticoagulant therapy), as well as patients with mild peptic ulcers and gastritis, etc. In addition,

　　Veterinary Medicine Paracetamol can be used in the synthesis of the drug Paracetamol, as well as as as organic synthesis intermediates, photographic chemicals and stabilizers of hydrogen peroxide.

Pharmacological Effects of Paracetamol / Acetaminophen Powder.

　　This product is antipyretic and analgesic, through the inhibition of cyclooxygenase, selective inhibition of hypothalamic thermoregulatory center prostaglandin synthesis, resulting in peripheral vasodilatation, sweating and to achieve the role of antipyretic, its antipyretic effect is similar to the strength of aspirin;

　　through the inhibition of the synthesis and release of prostaglandins, etc., to improve the pain threshold and play an analgesic effect, belongs to the peripheral analgesic, the effect of the weaker than aspirin, only for mild and moderate pain. It is a peripheral analgesic, weaker than aspirin, only effective for mild and moderate pain. This product has no obvious anti-inflammatory effect.

Production method of Paracetamol / Acetaminophen Powder.

　　It is obtained by acetylation of p-aminophen.

Method 1:

　　Add p-aminophenol into dilute acetic acid, then add glacial acetic acid, warm up to 150℃ and react for 7h, add acetic anhydride and react for another 2h, check the end point, after qualified, cool down to below 25℃, shake the filter, wash with water until there is no acetic acid flavor, shake dry, and get the crude product.

Method 2:

　　P-aminophenol, glacial acetic acid and acid containing more than 50% of the acid mother liquor together with distillation, evaporation of dilute acid rate of one-tenth of the total amount of distillation per hour, to be the internal temperature rises to 130 ℃ or more, sampling and checking the p-aminophenol residue is less than 2.5%, add dilute acid (content of 50% or more), cooling and crystallization. Shake filtration, first wash with a small amount of dilute acid, and then wash with a large amount of water until the filtrate is nearly colorless, the crude product.

　　The yield of method 1 is 90%, and the yield of method 2 is 90-95%. Refining method: put the crude product into the water when it is heated to nearly boiling. Warm up to fully dissolved, add activated carbon soaked with water, adjusted to pH=4.2-4.6 with dilute acetic acid, boiling for 10min. press filtration, filtrate with a small amount of sodium bisulfite. Cooled to below 20 ℃, precipitated crystals. Shake filtration, washing, drying to get API paracetamol finished product.

Other production methods are:

　　(1) Reduce p-nitrophenol with zinc in glacial acetic acid, and acetylate to get acetaminophen at the same time;

　　(2) the p-hydroxyacetophenone generated hydrazone, placed in an acidic solution of sulfuric acid, add sodium nitrite, transposition to generate acetaminophen.

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