Pharmaceutical Sulfamethoxazole Raw Materials Powder CAS 723-46-6 API Factory Supply

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Sulfamethoxazole Powder Usage and Synthesis.

We know that bacterial synthesis of thymidine, purine and ultimately DNA requires the folate derivative tetrahydrofolate as its cofactor. Most bacterial cells are not permeable to folic acid and must synthesise it with para-aminobenzoic acid (PABA). Sulfonamides, which are structurally similar to PABA, competitively inhibit the synthesis of dihy-dropteroic acid, the direct precursor of dihydrofolate, from PABA and pteridine. Mammalian cells, on the other hand, are not inhibited because they require preformed folic acid and cannot synthesise this. Therapeutic concentrations of the sulfonamide sulfamethoxazole are primarily bacteriostatic, but exposure to sulfonamides can produce a bactericidal effect, "thymine-deficient lethality", when bacteria are grown in substrates containing purines and amino acids and very low concentrations of thymine. 

This bactericidal effect has been demonstrated in human blood and urine (Then and Angehrn, 1973A and B; see also Pratt and Fekety, 1986). Sulfonamide-induced inhibition of mycobacterial cell growth can be reversed if certain substances (e.g., thymidine, purine, methionine, serine) are added to the growth matrix in vitro. This situation may be clinically important because the pus produced by cell destruction may contain many of these substances, so that drug action may be inhibited in purulent infections by the presence of such substances. Furthermore, PABA should not be present in the culture medium for in vitro drug sensitivity testing, as even trace amounts may interfere with the results.

Uses and functions of  Sulfamethoxazole Powder.

Sulfamethoxazole is used as an antimicrobial agent and is particularly effective against staphylococci and E. coli. It is mainly used for the treatment of avian cholera, etc.

Anti-infectives, used for urinary tract infections, respiratory tract infections, intestinal infections, Salmonella spp. infections, paediatric acute otitis media, prevention of rheumatoid arthritis

Sulfamethoxazole is mainly used for the treatment of acute and chronic urinary tract infections, but also for the prevention of meningitis and acute otitis media caused by influenza bacteria, etc.

Sulfamethoxazole can inhibit the growth of bacteria, especially strong effect on staphylococcus and E. coli, good effect in treating urinary tract infection and poultry mess.

Sulfamethoxazole is white crystalline powder; odourless, slightly bitter taste. It is almost insoluble in water, but soluble in dilute hydrochloric acid, sodium hydroxide test solution or ammonia test solution. The melting point of the product is 168～172℃.

Sulfamethoxazole is white crystalline powder; odourless, slightly bitter taste. The product is almost insoluble in water, soluble in dilute hydrochloric acid, sodium hydroxide test solution or ammonia test solution. Melting point The melting point of this product is 168～172℃.

Sulfonamide antibiotic, inhibits enzyme dihydropteroate synthase (enzyme dihydropteroate synthase), thus blocking the synthesis of dihydrofolate.

Pharmacological Effects of  Sulfamethoxazole Powder.

Sulfamethoxazole is a systemically applied intermediate-acting sulfonamide, which is a broad-spectrum bacteriostatic agent. Its antibacterial mechanism of action is due to its structural similarity to p-aminobenzoic acid (PABA), which can compete with PABA to act on the dihydrofolate synthase in bacteria, preventing the synthesis of bacterial dihydrofolate and thus inhibiting the growth and reproduction of bacteria. Sulfamethoxazole has antibacterial activity against both Gram-positive and negative bacteria, but bacterial resistance to this class of drugs is now widespread, with an increase in drug-resistant strains of staphylococcus spp, gonococcus spp, meningococcus spp, and enterobacteria spp bacteria. In addition, sulfamethoxazole is also active in vitro against microorganisms such as Chlamydia trachomatis, Nocardia asteroides, Plasmodium falciparum and Toxoplasma gondii.

Production method of  Sulfamethoxazole Powder.

Taking 5-methylisoxazole-3-carboxamide as raw material, it was degraded to 5-methylisoxazole-3-amine under the action of sodium hypochlorite, and then condensed with p-acetamidobenzenesulfonyl chloride to form 3-(p-acetamidobenzenesulfonamidato)-5-methylisoxazole, and then hydrolysed under alkaline condition to obtain 3-(p-aminobenzenesulfonamido)-5-methylisoxazole.

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