Veterinary Medicine Sulfamethoxazole Powder CAS 723-46-6 Raw Materials

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Sulfamethoxazole Powder Usage and Synthesis.

Veterinary Sulfamethoxazole, also known as Synthroid, is a broad-spectrum antimicrobial drug with particularly strong effects on staphylococci and Escherichia coli. Escherichia coli, Sulfamethoxazole Powder is used for the treatment of urinary tract infections and avian cholera. 

Sulfamethoxazole is a systemic application of intermediate-acting sulfonamides, Sulfamethoxazole Raw Materials can compete with PABA to act on the Sulfamethoxazole Raw Materials can compete with PABA to act on the dihydrofolate synthase enzyme in the bacterial body, preventing the synthesis of bacterial dihydrofolate, thus inhibiting the growth and reproduction of bacteria. preventing the synthesis of bacterial dihydrofolate, thus inhibiting the growth and reproduction of bacteria.

Uses and functions of Sulfamethoxazole Powder.

According to the absorption after oral administration, sulfonamides can be categorized into two groups, the first group is easily absorbed sulfonamides, which is characterized by rapid absorption, generally in 2-4h after taking the drug (long-acting drugs in 5h) blood concentration can reach the peak, this type of sulfonamides are mainly used for systemic infections. The other type is not easily absorbed or absorbed very little after oral administration, and most of it is excreted through the intestinal tract, which is mainly used for intestinal infections.

Clinically used in the treatment of urinary tract infections, respiratory tract infections, typhoid fever, and Salmonella infections, Pneumocystis carinii, Nucleococcal disease, etc., can also be used to prevent epidemic meningitis.

Some clinicians advocate the use of minocycline, ampicillin, or erythromycin in combination with sulfamethoxazole for the treatment of these infections, but there is no clinical data to prove that the combination therapy is indeed superior to sulfonamides alone. Cotrimoxazole (TMP/SMZ), minocycline (Minocin), and amikacin can also be used in the treatment of Nocardia asteroides infections.

Pharmacological Effects of Sulfamethoxazole Powder.

Sulfonamides have a wide antibacterial spectrum and have a certain inhibitory effect on most gram-positive and negative bacteria, but their antibacterial potency varies among different sulfonamides. With the wide application of sulfonamides, it will also be easy to form drug-resistant strains, especially Staphylococcus aureus has more chances to produce drug resistance.

We know that bacterial synthesis of thymidine, purine and eventually DNA requires the folate derivative tetrahydrofolate as its cofactor. Most bacterial cells are not permeable to folic acid and must synthesize it with para-aminobenzoic acid (PABA). Sulfonamides, which are structurally similar to PABA, competitively inhibit the synthesis of dihydrodropteroic acid, the direct precursor of dihydrofolate, from PABA and pteridine.

Mammalian cells, on the other hand, are not inhibited because they require preformed folic acid and cannot synthesize this. Therapeutic concentrations of the sulfonamide sulfamethoxazole are primarily bacteriostatic, but exposure to sulfonamides can produce a bactericidal effect, known as "thymine-deficient death", when bacteria are grown in substrates containing purines and amino acids and very low concentrations of thymine.

This bactericidal effect has been demonstrated in human blood and urine (Then and Angehrn, 1973A and B; see also Pratt and Fekety, 1986).

Sulfonamide-induced inhibition of mycobacterial cell growth can be reversed if certain substances (e.g., thymidine, purine, methionine, serine) are added to the growth matrix in vitro.

This situation may be clinically important because the pus produced by cell destruction may contain many of these substances, so that drug action may be inhibited in purulent infections by the presence of such substances.

Furthermore, PABA should not be present in the culture medium for in vitro drug sensitivity testing, as even trace amounts may interfere with the test results.

Production method of Sulfamethoxazole Powder.

Production method of Sulfamethoxazole Powder. Produced from 5-methylisoxazole-3-carboxamide by degradation, condensation and hydrolysis. Production method of Sulfamethoxazole Powder: 5-methylisoxazole-3-carboxamide is used as raw material, which is degraded to 5-methylisoxazole-3-amine under the action of sodium hypochlorite, and then condensed with p-acetamidobenzenesulfonyl chloride to form 3-(p-acetamidobenzenesulfonamide)-5-methylisoxazole, and then hydrolyzed under alkaline condition to obtain 3-(p-aminobenzenesulfonylamino)-5-methylisoxazole.

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