Aminophylline Powder Raw Material
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Overview of Aminophylline :Aminophylline is a compound salt composed of theophylline and ethylenediamine, belonging to the xanthine class of drugs. Its pharmacological effects mainly come from theophylline, which has the strongest effect on airway smooth muscle relaxation among xanthine alkaloids, and ethylenediamine can enhance its water solubility. Aminophylline is suitable for the treatment of bronchial asthma, obstructive emphysema and wheezing bronchitis. It can not only relax bronchial smooth muscle, but also strengthen heart, diuretic, crown expansion, anti-inflammatory, antagonistic adenosine receptor, immune regulation, excitation of respiratory center, and the treatment of diseases such as sick sinus syndrome and acute lung injury. Aminophyllinum is a commonly used bronchodilator that relaxes smooth muscles such as bronchus and biliary ducts directly to relieve spasms. Indirectly inhibit the release of histamine and other allergic substances; It can strengthen the contractility of the myocardium, increase the cardiac output and dilate the blood vessels of the coronary artery, but it is generally not used as an anti-angina drug. It has better diuretic effect. Its effective concentration is 10 ~ 15mg/L, over 20mg/L can cause poisoning. Aminophylline can cause intoxication in addition to a large dose or short-term frequent administration, the concentration of intravenous administration is too high or too fast can cause intoxication.
Pharmacological effects of Aminophylline :1. Relaxation of airway smooth muscle: aminophylline can relax airway smooth muscle and relieve bronchospasm.
2. Immunomodulatory and anti-inflammatory effects: a small amount of aminophylline can inhibit mast cells from releasing inflammatory transmitters and relieve spasm of airway smooth muscle; It can also inhibit eosinophil infiltration in the bronchus.
3. Enhance the contractility of respiratory muscle: Prevent diaphragm fatigue and respiratory failure by improving respiratory function.
4. Excite the respiratory center: make the breathing excited, enhance the depth of breathing, but the respiratory rate does not increase.
5. Strong heart: Acts on the heart to antagonize adenosine and prevent excessive release of adenosine, so as to expand coronary arteries and peripheral vessels, promote myocardial contraction and increase cardiac output.
6. Diuresis: increase renal blood flow and glomerular filtration rate, and inhibit the reabsorption of renal tubules.
CAS No. :317-34-0
Molecular formula :C9H16N6O2
Molecular weight :240.27
EINECS No. :206-264-5
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