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And Houpaku phenol for Houpaku phenol isomer, is by a phenylpropanoid side chain and another phenylpropanoid benzene nucleus polymerisation and become a dimer, called the so-called new lignans, in the camphor plant found more, for the traditional Chinese medicine Houpaku antimicrobial and anti-inflammatory active ingredient.
Uses of Honokiol.
It is anti-angiogenic, anti-tumour, and anti-anxiety.
It is bitter in taste, pungent in nature, and warm. Attributed to the spleen, stomach, lung and large intestine meridians. Drying dampness and eliminating phlegm, lowering Qi and removing fullness. It is used in treating dampness and stagnation in the middle, epigastric plague and vomiting and diarrhoea, food accumulation and stagnation of qi, abdominal distension and constipation, phlegm and cough.
It can be used in the treatment of acute enteritis, bacterial or amoebic dysentery, chronic gastritis.
Pharmacological effect of Honokiol.
At 15% concentration, it has inhibitory effect on the skin fungi of experimental animals, such as small bacillus, concentric trichophyton, red trichophyton, American trichophyton and so on.
Decoction of Hauppauge had certain ameliorating effects on substantial pathological damage in experimental viral hepatitis in mice. The antimicrobial activity of Huperzine on Gram-positive and acid-resistant bacteria is significant; the anticariogenic effect of Huperzine is very significant, with the lowest inhibitory concentration of 6.3 μg/ml, and its antimicrobial activity is stronger than that of the typical antimicrobial alkaloid berberine (MIC: 50 μg/ml).
The saturated aqueous solution of Huperzine and Huperzine volatile oil has certain antibacterial effects on Staphylococcus aureus, Streptococcus octococcus and Bacillus subtilis.
2.Effects on cardiovascular systemHypericin and and Hypericin inhibited thromboxane B2 formation in various cases, and intracellular Ca2+ elevation caused by arachidonic acid or collagen was also inhibited by both.
Huperzolol inhibited CaM-stimulated cyclic nucleotide phosphodiesterase activity, and Huperzolol bound to CaM in the presence of Ca2+, thereby antagonising its activation of phosphodiesterase. In addition, Huperzolol has a stimulatory effect on the basal activity of CaM-dependent phosphodiesterase.
3.Anti-tumour effectsHypericin and its hydroxymethyl derivatives have significant inhibitory effects on stage II skin tumours in mice. The three extracted constituents of Magnolia officinalis, Magnolol, and Magnolol and the monoterpene Magnolol are antagonists of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen (EBv-EA).4,5,6,7,8 The methanolic extract of Magnolia officinalis and its hydroxymethyl derivatives showed significant antitumour effects in mice.
The methanol extract and thujaplicin of A. thujaplica showed significant inhibitory effects on mouse skin tumours induced by in vivo phase II carcinogenicity experiments.
Extraction method of Honokiol.
1. thick Park extract (flow of ointment) of the production process take thick Park crushed, with ethanol infiltration 12 hours, placed in the percolation cylinder, with about 12 times the amount of ethanol percolation, collection of the percolated solution, decompression recovery of ethanol to the end of the flow of ointment. Yield of about 9%, the content of solids 85.0%, containing more than 11.0% of the thick Park phenol, containing and thick Park phenol more than 5.0%.
2. thick Park phenol, and thick Park phenol extraction separation take thick Park dry skin crude powder, add 1/5 amount (W / W) of lime powder, mix well, with 15-20 times the amount of distilled water percolation, the percolation solution with hydrochloric acid pH value of 2 ~ 3, stand.
Collection of precipitate precipitation, wash with distilled water to the precipitate pH value of 6 ~ 7, after drying add alumina (1:10) mixed well, placed in the extractor, with cyclohexane extraction. Cyclohexane extract was concentrated and cooled, white crystals were precipitated, and the crystals and mother liquor were filtered. Crystals with cyclohexane recrystallisation, that is, and Houbao phenol.
The mother liquor was concentrated to precipitate crystals, cyclohexane recrystallisation, to get colourless flaky crystals, that is, and Houpaku Phenol crystals. The yield of thujaplicin was 85%, and the yield of and thujaplicin was 74%.
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