Raw material Lentinan powder

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Product details

Lentinan powder Usage and Synthesis.

Shiitake polysaccharide is a polysaccharide isolated from the mushroom fruiting bodies or mycelium and is dominated by β-1,3-glucan with a branched chain at carbon atom position 6. It is an immune adjuvant that enhances the immune response in hormonal or post-infectious organisms.

Although shiitake polysaccharide has no immune-boosting effect on normal organisms, it did not have a direct anticancer effect in an in vivo animal screening test, but significantly promoted the transformation of lymphocyte cultures in vitro.

Shiitake mushroom polysaccharide is a special immune adjuvant with thymus-dependent T-cell orientation and macrophage involvement, which recognises antigenic macrophages in the spleen and liver, promotes the production of lymphocyte activating factors, releases a variety of helper T-cell factors, and enhances phagocytosis by host peritoneal macrophages. Shiitake mushroom polysaccharides are capable of immune activation and are effective in the adjuvant treatment of liver diseases.

Uses of Lentinan powder.

Used in conjunction with chemotherapeutic drugs for patients with gastrointestinal tumours, it can prolong survival time and prevent leukopenia or decrease in total serum protein.

It is effective in chronic viral hepatitis B. It can significantly improve the symptoms of patients, make serum ghrelin turn to normal or better, and adjust the immune function of patients.

Precautions: anaphylaxis, leukocyte and haemoglobin reduction symptoms may occasionally occur. Children and women of pregnancy and childbearing age should be used with caution.

Pharmacological Effect of Lentinan powder.

1, Anti-tumour. For example, shiitake polysaccharide obtained from shiitake mushroom has strong anti-tumour activity.

2, Enhancement of immunity. Shiitake mushroom polysaccharide is an ideal immune enhancer. Ginkgo biloba polysaccharide can promote the transformation of lymphocytes, enhance the phagocytosis of mouse abdominal macrophages, obviously promote the synthesis of liver protein nucleic acid as well as promote bone marrow haematopoiesis, and improve the humoral immunity.

Black fungus polyChemicalbook sugar can effectively improve the phagocytic index and percentage of mouse macrophages.

Black fungus polysaccharide can effectively increase the phagocytic index and percentage of mouse macrophages. Such as garlic, radish and other extracts of polysaccharides on T lymphocytes, B lymphocytes and macrophages have different enhancement effects, can enhance the body's cellular immune function.

3、Lowering blood sugar and blood fat. The polysaccharide with hypoglycemic effect is bovine milk glucan. Shiitake mushroom polysaccharide has the dissolving effect on cholesterol. Black fungus polysaccharide has the effect of alleviating atherosclerosis.

Extraction method of Bulk Lentinan powder.

At present, the extraction of mushroom polysaccharides is mostly carried out in hot water and dilute alkaline solution, avoiding strong acid and alkaline solution, otherwise it is very easy to cause glycosidic bond breakage and conformational changes in polysaccharides.

The commonly used separation and purification methods generally go through the steps of boiling water extraction, ethanol precipitation, dialysis and column chromatography.

Considering that there are other physiologically active components in mushrooms (e.g. adenine, tyrosine oxidase and vitamin D, etc.), the final product should be defined and the purpose of extraction should be clarified when determining the extraction method.

Generally, the mushroom substrate is first crushed, stirred and extracted with 90-100℃ water for 3-5h, repeated 2-3 times, and then extracted with 0.5 mol/L NaOH solution, initially the polysaccharides are divided into water-soluble and alkaline-soluble two parts.

Then the mushroom residue was removed, and the supernatant was dialysed or ion-exchanged to remove small molecule impurities, and the crude product could be obtained after ethanol or thiamine precipitation.

In the above extraction process, if the mushroom powder is treated with some compound enzyme preparation in advance, the rate of polysaccharide can be greatly improved.

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