Raw Materials Hesperetin Powder

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Hesperetin Powder Usage and Synthesis.

Hesperidin is a dihydroflavonoid mainly derived from the young fruits of the citrus genus Citrus in the family Rutaceae, such as oranges, lemons, thorns, hogsbane, Buddha's hand and so on. It is a pale yellow needle-like crystal or powder, easily soluble in ethanol, soluble in dilute alkaline solution, partially soluble in ether, slightly soluble in water, chloroform and benzene.

Hesperidin has a variety of biological activities, such as antioxidant, anti-inflammatory, anti-tumour, anti-virus, hypoglycaemic and so on.

Studies have shown that hesperidin is a uniquely potent Cisd2 activator that extends the lifespan and improves aspects of lean fat mass ratio, muscle fibre and strength, and cardiac function in mice.

As a result, hesperidin is widely used in health drugs and supplements, cosmetics and pharmaceutical foods. It is important to note that Hesperidin should be stored at low temperatures, and its content will decrease when exposed to air for a long period of time.

Uses and functions of Hesperetin.

It has stomachic, expectorant, cough suppressant, wind repellent, diuretic, antiviral, antibacterial, antireflux and stomachache effects. It is a promoter of cancer inhibition, aldose reductase inhibitor, inhibits lipolysis and promotes DNA biosynthesis. Effectively regulates the prevention and improvement of cardiovascular diseases.

Pharmacological Effect of Hesperetin.

(1) Antioxidant effect: Hesperidin can avoid the harmful effects of peroxidation by scavenging peroxynitrite ions.

(2) Anti-inflammatory effect: Hesperidin can inhibit the mediation of inflammatory mediators, thus indirectly inhibiting the inflammatory response. Compared with hesperidin, hesperidin has a stronger anti-inflammatory effect, and hesperidin C7 has an effect on its anti-inflammatory activity after connecting to brassinose.

(3) Hypolipidemic effect: Hesperidin can inhibit cholesterol-producing enzymes and esterases, thus achieving the role of hypolipidemic.

(4) Cardiovascular protection: Hesperidin has the effect of reducing blood lipids and vascular permeability, which can prevent thrombosis.

Hesperidin can also stimulate certain mitochondrial enzymes such as succinate dehydrogenase to protect the endothelial cells and tissues from hypoxia, preventing clotting caused by endothelial cell necrosis and inducing thrombosis.

In addition, hesperidin promotes anti-platelet coagulation activity by inhibiting the phosphorylation of PLCγ2 and its downstream signaling, which can prevent the formation of thrombus and benefit the cardiovascular system.

(5) Anti-tumour effect: Hesperidin has an antioxidant effect, thereby avoiding cancer caused by genetic changes induced by these factors.

Promote P-glycoprotein-mediated drug efflux from tumour cells, flavonoids (hesperidin, etc.) can change the permeability of the blood-brain barrier to vincristine, and also related to its concentration.

Low concentrations of flavonoids reduce the uptake of vincristine by endothelial cells in brain capillaries; conversely high concentrations have a promoting effect.

Product Method of Bulk Hesperetin Powder.

ThomasSeitz et al. chose methanol as the reaction medium for the hydrolysis of hesperidin, and concentrated sulfuric acid as the catalyst, and the reaction ended after heating and reflux reaction for 7.5h, and then added ethyl acetate solution, washed with water, and then concentrated after drying to obtain the crude product. The crude product was dissolved in acetone, added dropwise to dilute acetic acid solution, filtered, concentrated and dried to obtain pure product (yield 99%).

The methanol method is a simple synthesis process with the highest product yield, but the separation and purification of the product is cumbersome and requires the more toxic methanol as the reaction medium, so it is not in line with the green production requirements.

Wingard et al. improved the methanol method reported by ThomasSeitz. When the end of the hydrolysis reaction, the first decompression evaporation of excess methanol, under the protection of nitrogen the reaction solution is added directly to the aqueous phase heated reflux for 2h, cooling, there is a crude product precipitation (yield 85%), the crude product can be washed with water, you can get the 97% purity of hesperidin.

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