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Isorhamnetin (Iso) is a flavonoid compound isolated and purified from medicinal plants such as ginkgo and sea buckthorn, and is also widely found in the flowers, fruits and leaves of many other plants.
It has good anti-tumour, anti-myocardial hypoxia, ischemia, relief of angina pectoris, anti-arrhythmia, treatment of coronary heart disease and hypertension, scavenging of oxygen radicals, lowering of serum cholesterol, cardiovascular protection, promotion of blood flow, and other biological effects, and is widely used in clinical practice.
Uses of Isorhamnetin.
Isorhamnetin is a plant flavonoid found in fruits and herbs that has several pharmacological effects.
Firstly, isorhamnetin has a coronary dilating effect, increasing coronary blood flow.
Secondly, it inhibits platelet aggregation and anti-hemostatic effects, inhibiting the action of certain hemostatic components.
In addition, isorhamnetin has an anti-hepatotoxic component that inhibits hepatocyte toxicity in rats. In plants, isorhamnetin can regulate the reproductive ability of male plants.
In addition, isorhamnetin reduces serum and liver cholesterol concentrations, antilipid peroxidation, and reduces thiobarbituric acid-reactive substance TB in rat liver.
Isorhamnetin is also present in some plants. For example, cactus flowers contain glucosides of isorhamnetin and quercetin as well as isoquercitrin.
Pharmacological effect of Isorhamnetin.
1. Crown expansion effect. Increase coronary blood flow.
2. Inhibit platelet aggregation.
3. Antihemostatic effect. Inhibits the action of certain haemostatic components.
4. anti-hepatotoxic components. Inhibits CCl4 and GalN-induced hepatocyte toxicity in rats.
5. V9Z: Regulates the reproductive ability of male plants.
6. Reduces cholesterol concentration in serum and liver of rats.
7. Anti-lipid peroxidation. Reduces the amount of thiobarbituric acid reactive substance TBARS in the liver of rats.
8. Anti-tumour effects, isorhamnetin mainly inhibits tumour cell proliferation, induces apoptosis and inhibits signal transduction.
Isorhamnetin has significant anti-breast cancer effects, and its mechanism of action is related to the inhibition of cell proliferation pathway and promotion of cell apoptosis.
Extraction and synthesis methods of Bulk Isorhamnetin Powder.
Extraction of isorhamnetin from sea buckthorn pomace by ultrasonic method The principle of extracting isorhamnetin by ultrasonic method is that ultrasound produces cavitation between the solvent and the sample, which leads to the formation, growth, bursting and compression of bubbles within the solution, which contributes to the diffusion of the solute and improves the mass-transfer rate of the target material from the solid phase to the liquid phase.
Ultrasonic method can greatly reduce the extraction time, improve the rate of active ingredients and raw material utilisation.
Accurately weighing about 1.0g of sea buckthorn pomace → adding extraction solution → ultrasonic extraction → filtration → filtrate capacity → isorhamnetin The optimal process for isorhamnetin in sea buckthorn pomace was as follows: at 50℃, ultrasonic frequency 40kHz, extracting with V ethyl acetate ︰ V 95% ethanol as 4:6 extracting solution for ultrasonication for 2 times, each time for 1h, with material-liquid ratio of 1:25.
The content of isorhamnetin obtained by this method was up to 5.09 mg-g-1.
Chemical synthesis: Quercetin pentaacetate (Ⅱ) and 4',7-di-O-benzyl quercetin (Ⅲ) were obtained from quercetin (Ⅰ) as the starting material by acetylation, benzylation and methylation, 4',7-di-O-benzyl quercetin triacetate (Ⅳ) and 4',7-di-O-benzyl quercetin triacetate (Ⅲ) and 4',7-di-O-benzyl quercetin triacetate (Ⅲ) were obtained from quercetin (Ⅲ) and 4',7-di-O-benzyl quercetin triacetate (Ⅳ), respectively. O-benzyl-3'-methylquercetin (V) intermediates. Compound (V) was benzylated to give isorhamnetin (VI).
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