Ansamitocin P-3 CAS 66584-72-3 Raw Powder

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Ansamitocin P-3 Powder Usage and Synthesis:

Ansamitocin P-3 Powder is a potent anticancer drug that belongs to the ansamycin family of compounds. It is a semi-synthetic derivative of ansamitocin, which is produced by the bacterium Actinosynnema pretiosum. Ansamitocin P-3 CAS 66584-72-3 is a potent inhibitor of microtubule assembly, which is essential for cell division. Ansamitocin P-3 Supplier CAS 66584-72-3 Raw Powder Factory Wholesale.

It works by binding to the beta-tubulin subunit of microtubules, preventing their polymerization and causing cell cycle arrest and apoptosis in cancer cells. Ansamitocin P-3 has shown promising results in preclinical studies and is currently being evaluated in clinical trials for the treatment of various types of cancer, including breast, lung, ovarian, and prostate cancer.

Pharmacokinetics of Ansamitocin P-3 Powder:

Ansamitocin P-3 (AP3) is a small molecule ansamitocin antibiotic with various pharmacological activities such as anti-tumor, anti-tuberculosis and anti-bacterial; its components are P-0, P-1, P-2, P-3, P-3', P-4 and P-4', of which Ansamitocin P-3 is the main synthetic product, which prevents cell death by blocking the formation of microtubules. It has significant anti-tumor effects in vitro and in tumor-bearing animals.

Preparation Method of Ansamitocin P-3 Powder:

Method 1: A method of extraction and isolation and purification of ansamitocin P-3, the method comprising the following steps: 1) extracting the fermentation broth or solid fermentation medium at the end of fermentation with an extraction solvent to obtain an extraction solution; 2) concentrating the extraction solution obtained from step 1) until no extraction solvent flows out to obtain a concentrated extract crude A,

then adding neutral alumina and making it mixed well with crude A with an organic solvent 3) Spin evaporate the well-mixed crude A from step 2) to dry sand; 4) Add the organic solvent to the dry sandy crude A from step 3), shake and stand, and take the supernatant; 5) Concentrate the supernatant from step 4), add silica gel and spin evaporate to sandy, and elute with gradient by column chromatography to get anserine P-3.

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