Celastrol Powder CAS 34157-83-0 Raw Materials

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Celastrol Powder Usage and Synthesis.

Celastrol Powder, also known as nandrolizin, is a natural product with various biological activities, it has strong antioxidant effect, anti-cancer Celastrol Powder, also known as nandrolizin, is a natural product with various biological activities. 

Celastrol CAS 34157-83-0 is mainly derived from the root bark of Radix Rehmanniae, a plant of the family Euphorbiaceae, and it is one of the active Celastrol Raw Materials is used for the treatment of rheumatoid diseases such as Radix Rehmanniae Tablets and Radix Rehmanniae Polyglucoside Tablets. 

Celastrol Raw Materials is used for content determination/identification/pharmacological experiments, etc. It has strong antioxidant effect, anti It has strong antioxidant effect, anti-cancer neovascularization effect, anti-rheumatoid effect. 

Celastrol Raw Materials is a potent proteasome inhibitor and has been shown to induce apoptosis of cancer cells by inhibiting proteasome activity.

Application/Function of Celastrol Powder.

It is also known as "Broken Gut Herb", as the name implies, which shows its strong toxicity. In Mr. Jin Yong's writing, although Leigongteng is highly poisonous, it can cure the poison of love flowers after being refined by Chinese medicine. In modern medicine, one of the most important active ingredients of Radix et Rhizoma has been found to be used in the treatment of obesity, chronic inflammation and immune disorders. 2007, Radix et Rhizoma, Artemisinin, Radix et Rhizoma Methyl, Capsaicin and Curcumin were listed by the journal Cell as the five most likely and worthy of development as modern drugs. Five natural compounds. While high doses of celastrol are cardiotoxic, low doses of celastrol have been found to be cardiovascular protective, and its precise efficacy, intrinsic mechanism and unknown targets have attracted the attention of many scientists.

Pharmacological Effects of Celastrol Powder

• 1, Cytotoxic activity. Strong non-specific cytotoxic activity against P388 and a group of human cancer cell lines in vitro.
• 2, Immunomodulatory effect. Significantly inhibited the formation of hemolytic vacuolated cells in mouse spleen cells. Significantly inhibited the late onset hypersensitivity reaction in mice.
• 3, Anti-inflammatory effect. 0.5mg/kg significantly inhibited the formation of cotton ball granuloma in rats. 0.1~1.0μg/mL inhibited the production of PGE2 induced by yeast sugar; 1.0μg/mL inhibited the phagocytosis of macrophages.
• 4, The anti-peroxidation effect of rhodopsin is 15 times that of tocopherol, with IC50 of 7μM. It inhibits peroxidation inside and outside the mitochondrial membrane and directly scavenges free radicals.
• 5, Reglanthrin can prolong the sleep time of mice caused by sodium pentobarbital.
• 6, Immunosuppressive effect: inhibit the proliferation of splenocytes induced by PHA, ConA, LPS, etc. in mice, and inhibit the proliferation of lymphocytes.
• 7, Inhibit the fertilization ability of guinea pig sperm in vitro, the activity is significantly stronger than cottonwood acetate.
• 8, Anti-arthritic effect. Inhibits the activity of interleukin-1 in and outside mouse abdominal macrophages, inhibits the production of interleukin-2 in mouse splenocytes, and decreases the release of PGE2 from rabbit synovial cells.

Related Articles of Celastrol Powder.

A recent result published by Prof. Xiaokun Zhang's group at the School of Pharmacy, Xiamen University in 2017 in Molecular Cell, a subjournal of the leading international academic journal Cell, reveals the important targets and mechanisms of metabolic regulation of thujaplicins, which are isolated from the traditional medicinal plant Radix Rehmanniae, and identifies potential therapeutic approaches for obesity.

Along with artemisinin, thujaplicins are ranked by the journal Cell as one of the five traditional Natural medicinal compounds most likely to be developed into modern drugs.

The recent discovery of the super weight loss effects of thujaplicins has taken this traditional herbal ingredient by storm. However, the unclear target and molecular mechanism of thujaplicins have prevented its development as a modern drug.
The latest discovery by Prof.

Xiaokun Zhang's group is that thujaplicins can bind to the orphan nuclear receptor Nur77 in the cell nucleus, inducing a specific mechanism of action to clear damaged mitochondria, thereby inhibiting inflammation and obesity-related diseases. The experimental results clearly showed that ryanodine effectively inhibited weight gain in mice fed a high-fat diet.

This result identifies a specific target and a novel molecular mechanism of action of thujaplicins, breaking through a major challenge in the process of transforming natural products into modern drugs, laying a strong theoretical foundation for developing the medicinal value of thujaplicins and facilitating the development of drugs for the treatment of inflammatory diseases and obesity. The orphan nuclear receptor Nur77, which plays an important role in regulating metabolism, will be a potential drug target for the treatment of obesity.

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