Decitabine / 5-Aza-2'-deoxycytidine Powder CAS 2353-33-5 Raw Material

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Decitabine / 5-Aza-2'-deoxycytidine Powder Usage and Synthesis.

5-Aza-2'-deoxycytidine Powder is also known as Decitabine Powder, 5-Aza-2′-deoxycytidylic acid, Decitabine Raw Material is an adenosine analogue of natural 2′-deoxycytidylic acid, which reduces DNA methylation by inhibiting DNA methyltransferase. natural 2′-deoxycytidylic acid, which reduces DNA methylation by inhibiting DNA methyltransferase, thus inhibiting Tumour cell proliferation as well as well as preventing the occurrence of drug resistance, it is the most potent DNA methylation-specific inhibitor known to date, and belongs to the S-phase Decitabine Powder is indicated for the treatment of myelodysplastic syndromes (abbreviated as MDS).

Demethylating drugs can activate oncogenes in tumour cells and enhance the expression of regulatory genes such as differentiation genes, so that the treatment of MDS can be achieved.5-Azido-2'-deoxycytidine nucleoside (decitabine) exerts its antitumour effect after being phosphorylated.

It acts directly on DNA and inhibits DNA methyltransferase, resulting in DNA hypomethylation and cell differentiation and death. Decitabine inhibits DNA methylation in vitro without affecting DNA synthesis. It leads to demethylation of tumour cells and can restore the normal function of genes, which is important for controlling cell differentiation and proliferation. However, non-proliferative cells are not sensitive to decitabine.

Uses and functions of Decitabine / 5-Aza-2'-deoxycytidine Powder.

5-Aza-2'-deoxycytidine Powder is an epigenetic modifier that inhibits DNA transmethylase activity, leading to activation of genes in the presence of DNA demethylation (hypomethylation) as well as through remodelling of "open" chromatin; genes can be synergistically activated when demethylation is coupled with histone acetylation;

DNA demethylation or semi-demethylation is induced by 5′-Aza-deoxycytidine. DNA demethylation can regulate gene expression and increase nuclease sensitivity by "opening up" chromatin to detectable structures; this remodelling of chromatin structure allows transcription factors to attach to promoter regions of genes, assembly of transcriptional complexes, and gene expression

Decitabine has antitumour activity and exhibits a dual mechanism of dose difference. It is cytotoxic at high concentrations and demethylating at low concentrations. Acts on proliferating (S-phase) cells.

Pharmacological Effects of Decitabine / 5-Aza-2'-deoxycytidine Powder.

Decitabine belongs to the pyrimidine analogue (5-Aza-2'-deoxycytidine), which is the 2-deoxy-D-ribose form of 5-azacytidine.

Decitabine is converted by intracellular action to triphosphates, which are incorporated into DNA strands and inhibit DNA methylation, thereby increasing the expression of dormant genes, including tumour suppressor genes.

In vivo and in vitro studies have shown that decitabine induces differentiation of bone marrow cells, thereby normalising bone marrow development in some patients with myelodysplasia.

Decitabine (Deoxycytidine, Dacogen, 5-aza-2-deoxycytidine, 5-AZA-dC, 5-aza-CdR, NSC127716) is a DNA methyltransferase inhibitor that integrates into DNA, causes DNA hypomethylation, and stalls DNA replication in the intra -Decitabine is used to treat myelodysplastic syndromes (MDS).Decitabine induces cell cycle arrest and apoptosis in a variety of cancer cell lines.

Production method of Decitabine / 5-Aza-2'-deoxycytidine Powder.

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