HRK Factory Praziquantel Raw Materials Powder on sale
HRK Factory Praziquantel Raw Materials Powder on sale
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HRK Factory Praziquantel Raw Materials Powder on sale

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Praziquantel Usage and Function.

Praziquantel can kill adult schistosomiasis significantly. Its mechanism of killing insects, from the molecular level, is that praziquantel rapidly destroys the Ca2+ balance in the worm, on the one hand, it leads to the excitement of the worm body activity and muscle contracture, so that the parasitic schistosoma parasitic on the portal vein system can not be adsorbed on the blood vessel wall and is carried by the blood flow into the liver (liver migration), and then is damaged; Second, the syncytial cortex of schistosoma is damaged. In addition to affecting the absorption, excretion and secretion functions of the worm, resulting in the disturbance of glucose metabolism and enzyme system, the body surface antigen determining cluster of the worm is exposed, which can be recognized by the host immune system and attract a large number of inflammatory cells such as neutrophils, eosinophils and macrophages to gather around the worm and attack.

Praziquantel Powder

Uses of Praziquantel.

Praziquantel is a broad-spectrum anti-parasitic drug, which is effective against Schistosoma japonicum, Schistosoma mansoni and Schistosoma Egyptii, clonorchis sinensis, pneumofluke, Zingiberum, tapeworm and cysticercus. In particular, it has a powerful killing effect on tapeworms, and is the best kind of schistosomiasis drugs at present.

Praziquantel

Preparation of Praziquantel.

Product Method of Bulk Praziquantel Powder.

Phenylethylamine was used as raw material to acylate with chloroacetyl chloride, and then amination with potassium phthalamide to introduce amino group. Under the action of phosphorus oxychloride, 3, 4-dihydroisoquinoline derivatives were synthesized by cyclization. 1-aminomethyl tetrahydroquinoline was obtained by hydrogenation and hydrolysis, and cyclohexyl chloride and chloroacetyl chloride were successively acylated and dehydrochlorinated to obtain praziquantel.

Isoquinoline can also be used as raw material, and through Reissert reaction, cyanide and nitrogen are introduced to benzoyl on the l position, and then hydrogenated, while benzoyl group is transferred to the amino group of the side chain, and then chloroacetyl group is introduced to the amino group on the ring, and then cyclized, hydrolyzed, cyclohexyl formylated to obtain praziquantel.


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