Pharmaceutical intermediate Moxidectin Powder 113507-06-5

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Moxidectin Powder Usage and Synthesis.

Moxidectin is a semi-synthetic single-component macrolide antibiotic produced by the fermentation of Streptomyces and is a derivative of Nemectin. Macrolide antiparasitic drugs consist of two major groups, the avermectins and milbemycins.

Uses of Moxidectin.

Moxidectin is a macrocyclic lactone and semi-synthetic derivative of Nemectin. Moxidectin is a parasiticidal agent used for the prevention and control of filarial and intestinal worms. Moxidectin is found in veterinary medicines used to treat animals such as dogs, cats, horses, cattle and sheep.

Moxycodine started to be used as a veterinary dewormer. As a new generation of anthelmintic, moxidectin is highly effective in killing nematodes and body parasites, and has an excellent safety profile for animals.

It is superior to ivermectin in terms of dosage, formulation development, drug resistance and drug distribution in the body.

Physiological Effects of Moxidectin.

Moxidectin is very lipophilic, resulting in its high release. Moxicidine concentrates in the adipose tissue of the animal and is released for up to two months from administration. In goats, the oral bioavailability of moxidectin is 2.7 times lower and the half-life is 1.8 times shorter than in sheep.

Side Effect of  Bulk Moxidectin Powder.

Studies on Moxikertin have shown that side effects vary from animal to animal and may be affected by the product's formulation, method of administration, and dosage. An overdose of Moxidectin may potentiate the effects of the following drugs:

Gamma-aminobutyric acid (Gaba) in inside the central nervous system . In horses, an overdose may cause depressed lower lip ptosis tremors, lack of coordination when moving (ataxia), decreased respiratory rate (respiratory rate), lethargy and coma. If a dog licks moxidectin from the skin, this is a "spot-on" (topical) treatment.

It has the same effects as an overdose and may cause vomiting, salivation and neurological signs such as ataxia, tremor and nystagmus. Some sheepdogs can tolerate moxidectin, but other individuals are sensitive and may experience vomiting, salivation or transient neurological symptoms once ingested.

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