Pralidoxime Chloride CAS 51-15-0 Raw Materials Powder

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Pralidoxime Chloride Powder Usage and Synthesis.

Pralidoxime Chloride Powder (PralidoximeChloride), alias Pym Chloride, Chlorophosphidine, etc., the drug is an organophosphate antidote and other The drug is an organophosphate antidote and other antidotes, a cholinesterase resuscitator, an injectable class of drugs. 

Pralidoxime Chloride CAS 51-15-0 is mainly used for medium and severe organophosphorus poisoning. 

Pralidoxime Chloride Raw Materials can replace iodophosphate and has different degrees of reviving effect on the cholinesterase activity inhibited by acute organophosphorus insecticide, and it can be used as an antidote for the poisoning of many kinds of organophosphate insecticides. The antidote for organophosphorus poisoning.

The nucleophilic group of Pralidoxime Chloride can directly bind to the phosphorylation group of cholinesterase and then detach from cholinesterase together, so that cholinesterase can regain its original state and reappear active, thus relieving the symptoms of poisoning. For mild organophosphorus poisoning, the product can be applied alone to control the symptoms; for moderate and severe poisoning, it must be combined with atropine.

After intravenous administration, the effective concentration in the blood is quickly reached, and in large doses, it can enter the brain tissue through the blood-brain barrier and be excreted by the kidneys quickly without accumulation of poisoning, so it has been widely used and produced by several drug companies in China.

Application/Function of Pralidoxime Chloride Powder.

It can replace iodophoridine and has different degrees of reviving effect on the cholinesterase activity inhibited by acute organophosphorus insecticides, and can rescue the poisoning of many kinds of organophosphate insecticides, but it has no reviving effect on the cholinesterase inhibited by carbamate insecticides, and has poor effect on the rescue of malathion, trichlorfon, dichlorvos, leucovorin, meflofos, propamfos and octamethiphos.

This drug is an injectable drug. After intramuscular injection or static injection of this product, its peak concentration in the blood is maintained for 2~3h, and then gradually decreases. The half-life (t1/2) is 77 min. The drug is rapidly metabolized in body tissues and excreted in its original form and its metabolites in urine by kidney soon. It is used as an antidote for organophosphorus poisoning.

Production Method of Pralidoxime Chloride Powder

Pralidoxime Chloride Powder is a crotchety compound, its quaternary ammonium group can tend to the cationic site of the inactive phosphorylated cholinesterase bound to organophosphorus insecticide, and its nucleophilic group can directly combine with the phosphorylated group of cholinesterase and then jointly detach from cholinesterase, so that cholinesterase can restore its original state and become active again, and be inhibited by organophosphorus insecticide. The effect of reviving cholinesterase which has been "aged" for more than 36h is poor.

The effect of this product is obvious to the nicotine-like symptoms caused by organophosphorus insecticide, but weak to the toxic fowl-like symptoms, and not obvious to the central nervous system symptoms.

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