2,2'-Biphenol CAS 1806-29-7 Raw Materials Powder

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2,2'-Biphenol Powder Usage and Synthesis.

2,2'-Biphenol Powder is an off-white powdered solid with a melting point of 108-111°C. It is soluble in ethanol, ethyl acetate, dichloromethane, etc., but insoluble in hexane, petroleum ether, and benzene. It is soluble in ethanol, ethyl acetate, dichloromethane, etc., but insoluble in hexane, petroleum ether, and benzene. 

2,2'-Biphenol CAS 1806-29-7 structure is present in many biologically active natural products, drugs and drug precursors, and asymmetric catalytic ligands. ligands. ligands. 

2,2'-Biphenol Raw Materials are phenolic derivatives, which can be used in the synthesis of pharmaceutical intermediates.

Production Method of 2,2'-Biphenol Powder

2-bromophenol (0.2 mmol), pyridine ligand (0.02 mmol), and Mn powder (10.8 mg, 0.2 mmol) were added to a baked screw-cap tube with a stirring bar, and then the reaction tube was transferred to a glove box, where Ni-complex (0.02 mmol), KOt-Bu (1.1 eq.), and DMF (1.5 eq.) were added to the reaction system with a syringe. ) and DMF (1.5 mL), sealed the tube and then transferred the reaction mixture out of the glove box and stirred the reaction mixture for 12 h at 60 °C.

After the reaction, the mixture was quenched with concentrated hydrochloric acid, H2O, then the reaction mixture was extracted three times with ethyl acetate, the combined organic layers were washed with brine, the organic layers were separated and dried over anhydrous Na2SO4, filtered to remove the desiccant and the filtrate was concentrated by evaporation under vacuum, and finally the residue was purified by column chromatography on silica gel (eluent: hexane/EtOAc = 9:1 to 7:1) The target product molecule 2,2'-dihydroxybiphenyl was obtained.

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