Veterinary raw materials powder Oxolinic acid

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Oxolinic acid Powder Usage and Synthesis.

Quinolinone fungicide, used for rice seed treatment, known as the first fungicide with outstanding effectiveness against rice refractory blight bacterial disease (seedling spoilage). Before sowing, the seed treatment with chemicals can inhibit the occurrence of bacterial blight, and then the healthy seedlings can be transplanted to Honda to prevent bacterial blight. The mechanism of action is that it has a wide range of antibacterial activity against gram-negative bacteria, but it has weak activity against gram-positive bacteria and no activity against fungi.

Uses of Oxolinic acid.

It is used to treat bacterial diseases of fish, shrimp and other aquatic animals. It has a good therapeutic effect on furunculosis, vibriosis, sarcoidosis, red fin disease, red spot disease, canker disease, enteritis and so on. It has a strong broad spectrum, has strong antibacterial effect on gram-negative bacteria and some positive bacteria, and has no cross-property with antibiotics, but has no antibacterial effect on fungi and tuberculosis bacillus, with low dosage, good antibacterial effect and other advantages, aquaculture farmers think that it is one of the more ideal drugs for the treatment of aquatic animal diseases. It has considerable antibacterial activity against fish pathogens such as Vibrio anguillaris and aeromonas hydrophila.

Preparation of Oxolinic acid.

Product method of Bulk Oxolinic acid Powder.

Methylene dioxy aniline was prepared by nitration and reduction of methylene dioxy benzene. The synthesis of methylene dioxy aniline and diethyl ethoxymethymalonate were heated at 80 ~ 90℃ for 3h, and then reflow in xylene, then n-alkylation was carried out with ethane iodide in DMF solvent at 70 ~ 75℃ in the presence of sodium hydroxide, and the mixture was diluted with water and reflow for 3 ~ 4h. The hydrolysate was acidified with hydrochloric acid to produce quinobacillone.

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