6-Gingerol Powder CAS 23593-75-1 Raw Materials

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6-Gingerol Powder Usage and Synthesis.

6-Gingerol Powder is a synthetic pyrrole antifungal, inhibits a variety of pathogenic fungi, and can also be bactericidal at high concentrations. Antifungal 6-Gingerol Powder is used for systemic fungal infections as well as topical fungal infections. Antifungal 6-Gingerol Powder is used for systemic fungal infections as well as topical infections.Gingerol Raw MaterialsAnti-mycobacterial, used for the treatment of epidermal and deep-seated mycobacterial infections.

Uses and functions of 6-Gingerol Powder.

6-Gingerol can stimulate the mucous membrane, promote gastric secretion; in the intestinal tract can inhibit abnormal fermentation, promote gas emission; on the cerebral cortex and vasomotor center has an excitatory effect, can enhance blood circulation.

Modern medical research has confirmed that 6-Gingerol has antibacterial, antitumor, antioxidant, anti-inflammatory, antiplatelet effects, but also has a strong heart, prevention and treatment of cardiovascular disease, anti-coagulant, anti-ulcer, anti-vomiting, antidizziness, inhibit the synthesis of prostaglandins, cholagogues, antiseptic insecticides, insect repellent and skin care and cosmetic biological activities.

Pharmacological Effects of 6-Gingerol Powder.

6-Gingerol is a bioactive compound with antioxidant activity, anti-inflammatory and anti-tumor drugs. 6-Gingerol down-regulates the release of inflammatory cytokines from macrophages. It inhibits COX-2 expression by blocking p38 MAP kinase and NF-κB activity. White waxy solid, soluble in methanol, ethanol, DMSO and other organic solvents, from dried ginger, ginger, tulip.

Production method of 6-Gingerol Powder.

(1) Gingerol extraction and concentration: sliced ginger placed in a small multifunctional extraction and concentration tank, with a mass concentration of 80~95% ethanol at 1:6~15 material-liquid mass-volume ratio at 60~80 ℃ heating reflux extraction, the extraction time is 2~3 hours each time, each batch of ginger extracted 2~4 times, each time the extracted extract flowed into the said small multifunctional extraction and concentration tank, the unified concentration of ginger obtained extract;

(2) ginger phenol extraction: put said ginger extract in a glass reactor, extract with ethyl acetate, the number of times of extraction 2~4 times, combined to get the extract; the extract is recovered by rotary evaporator under reduced pressure to get the ginger phenol crude extract; the volume ratio of said ginger extract to said ethyl acetate is 1:2~4;

(3) silica gel column chromatography: dissolve said gingerol crude extract in ethyl acetate, and then add said gingerol crude extract 2~4 times the weight of silica gel mixing samples, solvent ethyl acetate evaporated dry, dry on silica gel column; with petroleum ether-ethyl acetate mixed solvent isocratic elution, thin-layer chromatography TCL detection, collection of eluent containing 6-gingerol part, with the rotary evaporator to recover said eluate under reduced pressure to obtain the crude 6-gingerol; said crude 6-gingerol was again put on a silica gel column, and the purer 6-gingerol was obtained by elution, detection, collection and recovery of solvent according to the above method;

(4) Preparation of HPLC purification: the purer 6-gingerol obtained from said step (3) was dissolved with methanol-water mixed solvent to prepare HPLC purification, eluted with methanol-water mixed solvent as mobile phase isocratic elution, the largest chromatographic peak was collected, and placed on a rotary evaporator and evaporated to a constant weight, which is to obtain the highly pure 6-Gingerol.

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