Veterinary medicine Tilmicosin phosphate CAS 137330-13-3

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Tilmicosin phosphate Usage and Synthesis.

Tilmicosin phosphate, also known as tilmicosin phosphate, is a chemical semi-synthetic macrolide antibiotic, for the current animal-specific new drugs, antibacterial spectrum is wide, on the gram-negative and positive bacteria have a strong inhibition of a variety of mycoplasma and spirochete also has a strong inhibitory effect. 

Clinically, it is mainly used for respiratory diseases caused by Actinobacillus pleuropneumoniae, Pasteurella haemolytica, Pasteurella multocida, as well as livestock and poultry forms.

Tilmicosin phosphate is used clinically for respiratory diseases caused by Actinobacillus pleuropneumoniae, Pasteurella haemolytica, Pasteurella multocida and the animal forms.

Uses and functions of Tilmicosin phosphate.

Tilmicosin has antimicrobial activity similar to that of macrolides and is effective against Gram-positive and some Gram-negative bacteria and mycoplasmas.

Preparation of Tilmicosin phosphate.

Dissolve tilmicosin solid in acetone according to mass:volume 1:5, mix thoroughly, heat to the reflux temperature of acetone, tilmicosin dissolved, filter. To the filtrate add 37% of the concentration of aqueous phosphoric acid solution, stirred thoroughly for 1 hour, the solution cooled down to room temperature, while stirring and slowly add butyl acetate drops, drops of butyl acetate for the volume of acetone 4 times, at this time the precipitation of a large number of crystals, keep stirring for 1 hour to be completely crystallised, centrifugal separation, the solid washed with cold butyl acetate for 2 times, drying to tilmicosin phosphate solid. Yield: 97%, purity, 99.1%.

Product Method of Bulk Tilmicosin phosphate.

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