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Florfenicol, also known as fluoromethylsulfonamycin, is a commonly used veterinary antibiotic, with wide antibacterial spectrum, strong bacterial inhibition, low minimum inhibitory concentration (MIC), the antibacterial effect of chloramphenicol and methicillin is 15-20 times, the drug concentration in the tissues can reach the peak in 60 minutes after the feed is administered, and it can control the disease rapidly, with high safety, non-toxicity, no residual characteristics, and without the potential potential to cause the potential danger of aplastic anaemia. It is suitable for use in large-scale farms.
It is mainly used for the treatment of bovine respiratory diseases caused by Pasteurella and Haemophilus.
It is mainly used for the treatment of respiratory diseases of cattle caused by Pasteurella and Haemophilus. It is also used for infectious diseases of pigs and chickens caused by sensitive bacteria and bacterial diseases of fish.
Uses and functions of Florfenicol.
Florfenicol can strongly interfere with bacterial protein synthesis, rapid absorption, wide distribution in vivo, long half-life, no side effects of re-obstruction, not easy to produce drug resistance, no residue, no cross-resistance.
Flubenicol can be used in the treatment of systemic infections in livestock, poultry and aquatic animals, with remarkable efficacy in respiratory infections and intestinal infections.
Poultry: Escherichia coli disease, salmonellosis, infectious rhinitis, chronic respiratory disease, duck plague and other mixed infections caused by various sensitive bacteria.
Livestock: pig, cattle, sheep and other infectious pleurisy, asthma, streptococcal disease, Escherichia coli disease, salmonellosis, infectious pleuropneumonia, wheezing, paratyphoid fever in piglets, yellow-white dysentery, oedema, atrophic rhinitis, swine pneumonic disease, piglets with red-white diarrhoea, lactation-free syndrome and other mixed infections.
Crab: appendage ulcer disease, yellow gill, rotten gill, red leg, fluorescent inflammation disease and red body syndrome.
Snappers: red neck disease, boils, perforation disease, rotting skin disease, enteritis, mumps bacterial septicaemia and so on.
Frogs: cataract syndrome, ascites disease, septicaemia, enteritis, etc.
Fish: enteritis disease, ascites disease, vibriosis, Edwardsiosis, etc.
Eel: dematosis septicaemia (unique efficacy), Edward's disease, erysipelas, enteritis, etc.
Pharmacological Effect of Florfenicol.
Florfenicol inhibits the extension of peptide chains by binding to the 50S subunit of bacterial ribosomes and hindering the transpeptidation of peptidyl transferase; at the same time, it selectively acts on the receptor of the 70S ribosomes of bacterial organisms and alters and interferes with the function of peptidyltransferase, thus doubly interfering with the synthesis of bacterial proteins.
The antibacterial spectrum and antibacterial activity of florfenicol are slightly better than that of methicillin, and it has strong antibacterial activity against a variety of Gram-positive bacteria, Gram-negative bacteria and mycoplasma, etc. The antibacterial activity of florfenicol is also better than that of methicillin. Bartonella haemolytica, Bartonella multocida is highly sensitive to this product, Streptococcus, Shigella dysentery, Salmonella typhi, Klebsiella, Escherichia coli and Haemophilus are sensitive to this product.
Chemical Properties of Bulk Florfenicol Powder.
Florfenicol is a synthetic monofluorine derivative of methylsulfonylmethamphetamine, white or off-white crystalline powder, odourless.
Slightly soluble in water and chloroform, slightly soluble in glacial acetic acid, soluble in methanol, ethanol, in dimethylformamide is very easy to dissolve. 0.5% aqueous solution of the pH value of 4.5 ~ 6.5. ethanol, polyethylene glycol 400 and dimethylformamide in the appropriate proportion of the mixture to increase the physical stability of the product in water.
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