Raw material intermediate Ciprofloxacin Lactate Powder

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Ciprofloxacin Lactate Powder Usage and Synthesis.

Ciprofloxacin Lactate (CiprofloxacinLactate) is a quinolone with broad-spectrum antimicrobial effect, which causes bacterial death by acting on the A subunit of bacterial DNA helicase and inhibiting DNA synthesis and replication.

Its antimicrobial activity is the strongest among the widely used fluoroquinolones, which is characterised by strong antimicrobial ability, low antimicrobial concentration, small toxic side effects, and bacteria are not easy to develop resistance to it, and it has a strong killing effect on the Gram-negative and part of the Gram-positive bacteria such as E. coli, dysentery bacilli, Proteus mirabilis, Pseudomonas aeruginosa, pulmonary diplococcus, and Staphylococcus spp.

Uses and functions of Ciprofloxacin Lactate.

It can be used for the following infections caused by sensitive bacteria:

1. Infections of the genitourinary system, including simple or complicated urinary tract infections, bacterial prostatitis, gonococcal urethritis, pyelonephritis, cervicitis (including those caused by enzyme-producing strains), etc. 3.

2. Respiratory infections include tonsillitis, pharyngitis, acute bronchitis and lung infections.

3. Infections of the digestive system, including gastrointestinal infections, cholecystitis, perianal abscesses, etc.

4. Infections of the organs include conjunctivitis, sinusitis, otitis media and so on.

5. Others can be used for bone and joint infections, skin and soft tissue infections and blood-borne infections, etc.

New broad-spectrum antibacterial drug with strong permeability, high blood concentration, low toxicity, not easy to produce drug resistance, and can be quickly distributed to other organs. This drug is easy to absorb orally, and the effect of intramuscular injection is better. New quinolone broad-spectrum antimicrobial drugs, very strong effect on gram-positive and negative bacteria.

Pharmacological Effect of Ciprofloxacin Lactate.

Ciprofloxacin Lactate is a third-generation synthetic quinolone with wide antibacterial spectrum and strong action. Bacteria highly sensitive to this product are gonococcus, staphylococcus aureus, streptococcus, Escherichia coli and so on.

Haemophilus ducreyi is also very sensitive to this product. It is the first broad-spectrum antimicrobial agent for the oral treatment of Pseudomonas aeruginosa infections. Weak against Chlamydia trachomatis and Mycoplasma solani, basically ineffective against Syphilis spirochetes. Tablets are effective when taken orally on an empty stomach.

Drug interactions of  Bulk Ciprofloxacin Lactate Powder.

Long-term use of large quantities by local absorption, can produce the same drug interactions with systemic drugs, as follows:

1, urine alkalinising agents can reduce the solubility of the product in the urine, resulting in crystalluria and nephrotoxicity.

2, cyclosporine and this product combined, can make the former blood concentration increased, must monitor cyclosporine blood concentration, and adjust the dose.

3、Combination of this product with theophylline may be due to the competitive inhibition of cytochrome P450 binding site, resulting in theophylline hepatic clearance significantly reduced, blood elimination half-life (t1/2b) prolongation, blood concentration increased, theophylline toxicity symptoms, such as nausea, vomiting, tremor, agitation, agitation, convulsions, palpitations, etc., therefore, should be measured when the combination of theophylline blood concentration and adjustment of the dosage.

4, Ciprofloxacin lactate and anticoagulant warfarin can enhance the latter's anticoagulant effect, the combination should be closely monitor the patient's prothrombin time.

5, probenecid can reduce the product from the renal tubular secretion of about 50%, when used in combination can be due to the increase in blood concentration of the product and toxicity.

6, Ciprofloxacin lactate interferes with the metabolism of caffeine, resulting in reduced caffeine clearance, blood elimination half-life (t1/2b) prolongation, and may produce central nervous system toxicity.

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