Raw material intermediate Thiamphenicol Powder

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Thiamphenicol Usage and Synthesis.

Methylsulfonylmethamphetamine also has a strong immunosuppressive effect and is an excellent immunosuppressant. Its mechanism of action is significantly different from other immunosuppressive agents, and its immunosuppressive effect is several times higher than that of chloramphenicol. It is an effective prolonging agent for reflective transplantation and surgical allogeneic homogeneous transplantation.

Domestic production of methicillin enteric-coated tablets are mainly used for the treatment of respiratory tract, urinary tract, intestinal tract and other infections caused by sensitive bacteria such as Haemophilus influenzae, Escherichia coli and Salmonella spp.

Uses and functions of Thiamphenicol.

Thiamphenicol is a broad-spectrum bacteriostatic agent. It has an inhibitory effect on most Gram-positive and Gram-negative bacteria.

Especially for gram-negative bacilli, such as Escherichia coli, Salmonella, typhoid fever, aerobic bacilli, Klebsiella, Bartonella, Brucella, dysentery bacilli, etc., gram-positive bacteria such as anthrax, staphylococcus, corynebacterium, pneumococcus, streptococcus, enterococci, and actinomycetes, which are also more sensitive to the role of the bacterium.

However, it is not as effective as penicillin and tetracycline against Gram-positive bacteria. It is also effective against Leptospira, some mycoplasmas, some chlamydia and rickettsiae.

There is complete cross-resistance between this product and chloramphenicol, and partial cross-resistance with tetracyclines.

Pharmacological Effect of Thiamphenicol.

Thiamphenicol is the analogue of chloramphenicol, the antibacterial spectrum and antibacterial effect is similar to chloramphenicol, with a broad-spectrum anti-microbial effect, including aerobic gram-negative and gram-positive bacteria, anaerobic bacteria, Rickettsiae spp., spirochetes and Chlamydiae spp.

1、Methylsulfonylmethamphetamine has bactericidal effect on the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis.

2、It is only bacteriostatic for the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus grasshopperus, group B haemolytic streptococcus, Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes, Salmonella typhi, Salmonella paratyphi, Shigella spp. and anaerobic bacteria such as Bacteroides fragilis.

3, the following bacteria are usually resistant to chloramphenicol: Pseudomonas aeruginosa, Pseudomonas aeruginosa, Enterobacteriaceae, Serratia marcescens, indole-positive Proteus spp, methicillin-resistant staphylococci and Enterococcus spp.

4, This product is a bacteriostatic agent, reversibly binds to the 50S subunit of the bacterial ribosome, so that the growth of peptide chain is blocked (probably due to the inhibition of the role of transpeptidase), thus inhibiting the formation of peptide chain, thus preventing protein synthesis, and chloramphenicol is completely cross-resistant to each other.

Since methicillin does not bind to glucuronic acid in the liver, it has high antibacterial activity in vivo. It also has strong immunosuppressive effects.

Adverse Reaction of  Bulk Thiamphenicol Powder.

1、Abdominal pain, diarrhoea, nausea, vomiting and other gastrointestinal reactions may occur, the incidence of which is less than 10%.

2. Occasionally, allergic reactions such as skin rashes are seen.

3, premature infants and newborns have not been found in the "grey baby syndrome", only one case reported transient skin and pallor.

4, the product can cause toxic reactions of the hematopoietic system, mainly manifested as reversible inhibition of erythropoiesis, leukocyte and platelet reduction, the occurrence of aplastic anaemia is rare.

5, the central nervous system reaction mainly manifested as headache, drowsiness, dizziness and peripheral neuritis. Long-term treatment with methylsulfonylmethoxazole in people with neurological lesions can cause symptoms such as hyperalgesia, pain on touch and nociception.

Symptoms are more severe in the feet than in the hands and may improve after discontinuation of the drug, but not completely.

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