Pharmaceutical raw material Lutin Powder

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Product details

Lutin Powder Usage and Synthesis.

Luteinising hormone is a steroid hormone containing 21 carbon atoms secreted by the luteal cells of the ovary and an intermediate product in the synthesis of all steroid hormones, belonging to one of the progestins.

There are two types of crystals, namely α-type and β-type, two types of crystals have the same physiological activity, α-type is precipitated from dilute ethanol, for the orthorhombic crystal system of white prismatic crystals, β-type for the orthorhombic crystal system of white needle-like crystals, both are insoluble in water, soluble in ethanol, ether, chloroform, acetone, dioxin and concentrated sulfuric acid.

Uses and functions of Lutin.

Progesterone has a significant morphological effect in vivo on the oestrogen-primed endometrium, which is necessary for the maintenance of pregnancy.

In the late menstrual period with estrogen to promote the development of endometrial proliferation, so that from the proliferative phase to the secretory phase, for the fertilization of the egg bed and embryonic development to create conditions; in the menstrual period to make all the endometrial shedding; in the gestation period to inhibit uterine motility and the sensitivity of the oxytocin, there is a role in the anaesthesia, and with estrogen to promote further development of the mammary glands, in preparation for breast milk production; a large dose of Large doses can inhibit the secretion of luteinising hormone by the anterior pituitary through the feedback regulation of the hypothalamus-anterior pituitary-ovarian axis, thus inhibiting ovulation and playing a contraceptive role.

Progesterone can be used for habitual abortion, preeclampsia, functional uterine bleeding, haemorrhagic disorders, dysmenorrhoea, endometriosis, amenorrhoea, ureteral calculi.

Prostatic hyperplasia, sleep apnoea syndrome and intractable cirrhotic ascites.

Function of Lutin Powder.

1, Progesterone can maintain pregnancy in female animals and lead to a series of physiological changes in pregnant animals, such as inhibiting oestrus in female animals.

2、Promote the thickening of the mucous membrane layer of the uterus, the curvature of the glands, and the increase of secretion function.

3. Inhibit peristalsis of the uterus and cause the cervix to contract and secrete viscous fluid. These physiological changes provide suitable k-environmental conditions for the operation, growth and development of the early embryo, attachment and the continued growth of the foetus after attachment.

4. A small amount of progesterone synergises with estrogen to promote estrus in female animals. Progesterone synergises with prolactin to promote the development of mammary glands.

5, luteinising hormone is involved in the feedback regulation of the hypothalamus and anterior pituitary gland, so that the secretion of animal reproductive hormones is coordinated and balanced. In vivo, the progesterone content in the follicular phase of various domestic animals is less than 1 ng/ml, about 4 ng/ml in the luteal phase of cattle, and about 18 ng/ml in the gestation phase.

Product Method of Bulk Lutin Powder.

Obtained by the oxidation of Haumeaenolone.

Dry toluene into the dry reaction pot, add cyclohexanone and Haumea enol ketone, stirring to dissolve, evaporate toluene dehydration to exhaustion, quickly add aluminium isopropanol, oxidation reaction at 115 ℃ for 2h, cooled to 80 ℃ or so, under stirring to add 5% dilute sulfuric acid, static stratification, separated from the aqueous layer, the toluene layer is washed with water to neutral and then carry out steam distillation, evaporate the toluene and cyclohexanone. Cooling, filtration, filter residue with petroleum ether stirred into slurry, filtration, washed with petroleum ether, dried progesterone crude.

The crude product was dissolved in ethanol, decolourised with activated carbon and recrystallised as a finished product with a yield of 80%.

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