Dexamethasone Raw Materials Dexamethasone Powder

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Dexamethasone Powder Usage and Synthesis.

Dexamethasone is one of the commonly used drugs in clinical practice. It is often used together with other drugs in the clinic, and it has anti-inflammatory, antitoxic and anti-allergic effects. But it has no therapeutic effect on the disease, can only reduce or inhibit the manifestation of inflammation, so in the clinical use of the drug must pay attention to, generally not used alone to use with other drugs to play a better role.

The anti-inflammatory effect and control of skin irritation are more pronounced than that of prednisone, while the effects on sodium retention and promotion of potassium excretion are milder, and the inhibitory effect on the pituitary-adrenocortical axis is stronger. Intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate peaked the blood concentration at 1 hour or 8 hours, respectively.

Uses and functions of Dexamethasone.

Dexamethasone (dexamethasone sodium phosphate EP impurity A) is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.

It is mainly used as an anti-inflammatory and anti-allergic agent for rheumatoid arthritis and other collagenous disorders, among others.

Pharmacological Effect of Dexamethasone.

Dexamethasone (DSMS), also known as flumethasone, fluoromethylprednisolone, and dexamethasone, is a synthetic adrenocorticotropic hormone. It is a glucocorticoid hormone anti-inflammatory and anti-allergic drug, and its pharmacological effects are mainly anti-inflammatory, antitoxic, anti-allergic and anti-rheumatic, and it is widely used in clinical practice.

In recent years, the European Union believes that the consumption of beef containing hormones such as oestradiol, luteinising hormone and medroxyprogesterone can disrupt the normal functions of the human endocrine, growth and development, immune system, reproductive system, etc., and may also be carcinogenic and teratogenic, and thus prohibit the use of such hormones in animals.

In addition, dexamethasone is also used as an animal growth regulator to promote animal protein synthesis and metabolism and increase meat production, and was once widely used as a livestock, poultry, use.

However, through long-term laboratory research found that dexamethasone can make experimental animals cancer and gene mutation, dexamethasone and its residues on humans and animals have obvious toxic side effects, the use of high doses of dexamethasone can lead to muscle atrophy, growth inhibition and other side effects.

It is also deduced that cancer and gene mutation may occur in human beings after long-term use of this kind of drugs or long-term consumption of livestock and poultry with this kind of growth promoter. Therefore, it is prohibited to use these drugs in treatment and feed.

Product Method of Bulk Dexamethasone Powder.

A new process method for the production of dexamethasone 21-hydroxyl, using intermediate 21-acetate as a substrate, semi-solubilising the substrate with an appropriate amount of methanol containing 0-10% chloroform as a solvent, hydrolyzing the substrate with a base as a catalyst, neutralising the reaction with acetic acid after the reaction is complete, concentrating the reaction solution under reduced pressure to the appropriate volume, cooling down the temperature, filtering, rinsing the filter cake with water, and drying to obtain the 21-hydroxyl.

This process can shorten the production cycle, improve the quality and yield of 21-hydroxy, and reduce the content of impurities in 21-hydroxy. Safety Information

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