Catharanthus Roseus Extract Powder

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Catharanthus Roseus Extract Powder Usage and Synthesis.

Periwinkle is slightly bitter in taste, cool in nature and belongs to the liver meridian, with the effects of detoxification, clearing heat and calming the liver. Periwinkle extract is rich in terpene alkaloids, dimeric indole alkaloids, monoindole alkaloids and other alkaloids and flavonoids, which have therapeutic effects on a variety of tumours, hypertension, carbuncle sores and poisons, scalded, malaria, diarrhoea and Hodgkin's disease, but also has hypoglycemic, diuretic and other pharmacological activities.

Uses of Catharanthus Roseus Extract.

Anti-cancer, lowering blood pressure. Used for hypertension, malignant lymphogranuloma, choriocarcinoma, acute lymphatic leukaemia, childhood lymphatic leukaemia.

1. 22 cases of Hodgkin's disease, 11 cases of lymphosarcoma, 1 case each of malignant reticulocyte hyperplasia, mycosis fungoides, leukaemia, green tumour, mediastinal tumour, and 6 cases of reticulocyte sarcoma were treated with Vincristine Sulphate in tumour. As a result, there were 4 cases of complete disappearance, 15 cases of obvious effect, 12 cases of effective, 6 cases of ineffective, 3 cases of deterioration, 3 cases of unknown, and the total effective rate was 72.1%.

2.Acute lymphatic leukaemia vincristine sulphate 10mg (1 dose), 2 times a week, intravenous injection, the total amount of 50mg. 5 cases of acute lymphatic leukaemia, 1 case of subacute lymphatic leukaemia, 2 cases of acute and chronic granulocytic leukaemia, 2 cases of complete disappearance and 3 cases of apparent effect.

3. 12g of periwinkle, 9g of Siegesbeckia, 6g of cassia seed and 6g of chrysanthemum in water, have good effect on lowering blood pressure.

Pharmacological Effect of Catharanthus Roseus Extract.

1.Anti-cancer effect of periwinkle alkaloids and periwinkle alkaloids have anti-cancer effect. The anticancer spectrum of periwinkle alkaloids on animals is wider than that of periwinkle alkaloids; the alkaloid Ac-875 proposed from periwinkle has obvious inhibitory effect on mouse Ehrlich's ascites carcinoma, ascites-type hepatocellular carcinoma and rat ascites-type Yoshida sarcoma.

The mechanism of anticancer effect is that both periwinkle alkaloids and periwinkle alkaloids can denature the protein of spindle filament microtubule in the cell, so that the formation of spindle humour filament is impaired, thus inhibiting the mitosis of the cell, so that the cell division stops in the middle stage; in addition, they can also inhibit the synthesis of DNA and inhibit the enzyme of RNA polymerase, so that the synthesis of RNA is impeded.

2.Antihypertensive effect of periwinkle alkaloids injected intravenously, on anaesthetised cats and rabbits have antihypertensive effect, blood pressure falls fast, different from the slow fall of rosmarinus officinalis alkaloids preparation, and in the lowering of blood pressure at the same time accompanied by deepening of respiration, the amplitude of the larger; cut off the vagus nerve or atropine does not affect the effect of its lowering of blood pressure. Total alkaloids also have the effect of coronary vasodilatation (belonging to the antispasmodic ganglion blocker).

3. Hypoglycaemic effect of foreign folk with periwinkle leaves and whole plant treatment of diabetes. Leaf of the aqueous extract of normal and tetroxypyrimidine-induced diabetes in rabbits and dogs can also reduce blood glucose.4. Diuretic effect of the extract of vindolinine (Vindolinine) on saline loaded rats have diuretic effect.5. Other effects of periwinkle alkaloids have no excitatory effect on the isolated uterus and intestinal tubes, and inhibitory effect on the isolated heart of large doses.

Leaves of the aqueous extract of normal and tetraoxymethylpyrimidine-induced diabetes in rabbits and dogs can also reduce blood glucose.

4. Diuretic effect of the extract of Vindolinine (Vindolinine) on saline loaded rats have diuretic effect.

5.Other effects of periwinkle alkaloids on the isolated uterus and intestinal tubes have no excitatory effect, large doses of isolated heart has inhibitory effect. It can be used as hemostatic agent when uterine bleeding is introduced abroad, and its root can be used for abortion. All its alkaloid parts have different degrees of antibacterial effect.

Cynthetics of Bulk Catharanthus Roseus Extract Powder.

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