Natural Plant Extract Senna Leaf Extract Powder

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Senna Leaf Extract Powder Usage and Synthesis.

Senna is a shrub that grows in India, Pakistan, southern China and many other places. Its name is derived from the Arabic word "sena" and has been used in ancient Indian and Greek medicine since the 9th century. The shrub grows to a height of about two feet and has green stems, pods and yellow spade-shaped leaves. Its alternate leaves are evergreen with four to five pairs of lanceolate or obovate grey-green fragile leaflets. The flowers are small, yellow, with five clawed, untidy petals. The fruit is enclosed in a rectangular pod about 5cm long. The leaves and pods or fruit are used medicinally.

Uses and functions of Senna Leaf Extract.

It has certain antibacterial function, and can be used in acute pancreatitis, dysentery, epidemic haemorrhagic fever, cholecystitis, postpartum breastfeeding. Suitable for medicine

The active ingredient in senna is known as sennoside.

The molecules of this component are converted by microorganisms in the colon into another substance, anthrone rhubarbate, which possesses beneficial effects in stimulating colonic activity (it accelerates peristalsis and improves digestion) and increasing fluid secretion.

The light diarrhoeal action of senna glycosides and their active metabolite anthrone rhubarbate are thought to inhibit the absorption of water and electrolytes from the colon, thereby increasing the volume and pressure of the intestinal contents.

Its will stimulate a propulsive tightening movement of the colon. In addition, the stimulatory effect on active chloride secretion increases the intestinal water and electrolyte contents.

These changes in active electrolyte transport are dependent on the presence of calcium on the plasma membrane surface.

The light diarrhoeal effect of senna glycosides is partly mediated via a stimulatory effect on colonic fluid and electrolyte secretion, and this secretory capacity is modulated by a stimulatory effect on the process of endogenous prostaglandin formation.

Sennosides may be prepared as enemas or suppositories or mixed with stool softeners or bulk fibre laxatives to form combination laxatives.

Pharmacological Effect of Senna Leaf Extract.

1, antibacterial effect: 10% senna leaf solution on Escherichia coli, Escherichia coli, dysentery bacillus, Streptococcus aureus and white bead-containing bacteria have obvious inhibitory effect.

Some hydroxyanthraquinone components in senna have certain antibacterial effect.

Alcoholic extract of Senna ovata has inhibitory effect on various bacteria such as Staphylococcus and Diphtheria, Typhoid, Paratyphoid, Escherichia coli, etc., and its aqueous extract is only effective on S. Typhi.

Senna water extract (1:4) in the test tube on the Audouin's small spores of lichen planus and astro nucella and other skin fungi have an inhibitory effect.

2, haemostatic effect: Senna powder can increase platelets and fibrinogen after oral administration, can shorten the coagulation time, re-calcium time, thromboplastin time and clot contraction time, and help to stop bleeding. Senna in the crystal fibres and calcium oxalate cluster crystals have a local haemostatic effect.

3, the effect on the digestive system: senna is a laxative, recent studies have found that this drug can not only stimulate the colonic mucosa to release PG (and that this is a diarrhoea mechanism), but also can make the rat gastric body, the gastric sinus part of the PG level increased significantly.

The ability of senna to prevent damage to the gastric mucosa by high doses of anti-inflammatory painkillers may be due to its ability to antagonise the inhibitory effect of the latter on gastric mucosal cyclooxygenase (PG synthase).

As the diarrhoeal effect of PG is also a protective effect on the intestinal tract, so senna by stimulating PG synthesis on the gastric mucosa to produce a protective effect, and its stimulation of PG synthesis diarrhoeal effect is consistent.

4, muscle relaxation and antispasmodic effect: Senna has an arrow poison like effect, can block acetylcholine in motor nerve endings and skeletal muscle, so that muscle relaxation.

Senna in some of the hydroxyanthraquinone components have a certain antispasmodic effect.

5, other effects: the seeds of Senna auriculata have lowered fasting blood sugar in dogs, the whole plant also contains cardiac glycosides.

Extraction method of Bulk Senna Leaf Extract Powder.

Narrow-leaved senna leaves are picked before flowering, dried in the shade, graded according to leaf size and quality, and packed under pressure. Sharp-leaved senna cut the branches when the fruit is ripe, pick the leaves, sun-dried, according to the complete leaves and broken leaves are packed separately.

Senna original herb crushed into a coarse powder, add water at 70 ~ 80 ℃ extraction, separated from the extract, placed in a centrifugal film evaporator to concentrate (below 45 ℃) to about 10 boe (thermal measurement), the concentration process can not exceed 2 hours, the temperature can not exceed 60 ℃, spray drying.

The product produced by this process contains senna glycosides at about 3%, yield of about 10%.

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