Promestriene Powder CAS 39219-28-8 Powder Raw Material

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Product details

Promestriene Powder Usage and Synthesis:

Promestriene Powder CAS 39219-28-8 is a topical estrogen supplement. Promestriene Powder is the first-line drug raw material for the treatment of vaginal infection and atrophic vaginal disease. Promestriene Raw Material is safe and effective, and is well tolerated by patients. Promestriene Powder is a chemically synthesized steroidal estrogen.

Proestrene is a special estradiol diether. Its special molecular structure enables it to have biological effects in situ without metabolism, and its biological half-life is <24h. Therefore, when administered vaginally, the drug directly acts on the vaginal mucosa without being absorbed by the mucosal tissue, and estrogen does not accumulate in the body, especially in estrogen-sensitive organs far away from the vagina. Clinical observations further pointed out that local application of promestriene has no effect on plasma sex hormone binding protein (SHBG), estrone (E1), estradiol (E2), and can effectively prevent and treat atrophic vaginitis. local estrogen action. Compared with other drugs, promestriene has the advantage that it is almost not absorbed through the vagina, so it can effectively avoid the systemic risks brought about by long-term local estrogen supplementation through the vagina, and has fewer adverse reactions, and there is no systemic effect to a lesser extent. With mild side effects and high safety, most patients are willing to accept it. It is a good choice for the treatment of atrophic vaginitis, especially for those patients with estrogen-dependent diseases.

Pharmacokinetics of Promestriene Powder:

This product is a chemically synthesized steroidal estrogen, which mainly acts locally on the vaginal mucosa, thickens the mucosa, balances the pH of the vagina, improves the vaginal environment, enhances the resistance of vaginal tissues, reduces vaginal infections, and has a good effect on improving atrophy. It acts on the local symptoms of vulva and vagina in vaginitis, and produces local estrogen effect on the mucous membrane at the bottom of female reproductive tract. Promestriene is a topical drug that has no systemic estrogenic effects on organs remote from the vagina when applied intravaginally. Common dosage forms of promestriene include ointment, capsules, and capsules. For estrogen drugs. For the treatment of vaginal atrophic lesions caused by estrogen deficiency. Proestrene cream has an androgenic effect on the lower channel of the female genitalia, which can restore its nutrition and promote the proliferation of the underlying cells of the vagina. And evolve into middle layer and surface layer cells, so that the thickness of the whole epithelium increases, middle layer and surface layer epithelial cells differentiate and mature. Synthesize and secrete glycogen; at the same time, it can promote the regeneration of Saccharomyces vaginalis, produce lactic acid, and restore its normal acidic physiological environment. Promestrine can promote the repair of cervical-vaginal-vulvar mucosal epithelial injury. API Raw Material Factory

Clinical Application of Promestriene Powder:

1. Cold cream or cream: for atrophic lesions of the vulva, vestibule and vaginal ring.

2. Vaginal capsules: used for vaginal atrophy caused by estrogen deficiency; the mucosa of the cervix, vagina and vulva is delayed due to childbirth, local surgery or physical therapy (such as laser, freezing or burning, etc.) Scab delayed.

Proestrene Cream: For atrophic lesions of the vulva, vestibule and vaginal ring.

Promestriene vaginal capsules: for the treatment of vaginal atrophic lesions caused by estrogen deficiency.

Proestrene Vaginal Capsules/Proestrene Vaginal Soft Capsules: For vaginal atrophy caused by estrogen deficiency; the mucosal parts of the cervix, vagina and vulva are prolonged due to damage caused by childbirth, local surgery or physical therapy. Scab delayed.

Mifepristone Powder Raw Materials can be made into drugs with the following properties:

(1) Promestriene cream: white cream with emulsion base, with special odor.

(2) Proestrel vaginal capsules: Oval capsules containing milky white viscous liquid.

(3) Promestriene vaginal capsules: light yellow oval soft capsules containing milky white milky liquid.

(4) Promestriene vaginal soft capsule: light yellow oval soft capsule, the content is colorless transparent or translucent oily liquid.

Specification:

(1) Promestriene cream: 1% (g/g); 15g/tube or 30g/tube.

(2) Promestriene vaginal capsules: 10mg.

(3) Promestriene vaginal capsule: 10mg.

(4) Promestriene vaginal soft capsule: 10mg.

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