Azosemide CAS 27589-33-9 Powder Raw Materials

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Azosemide Powder Usage and Synthesis:

Azosemide, chemically known as 2-chloro-5-(1H-tetrazol-5-yl)-4-(2-thienylmethylamino)benzenesulfonamide, is a medullary loop diuretic that inhibits the reabsorption of sodium, potassium and chloride ions from the ascending portion of Henry's loop and was first marketed in Japan in 1987 as a tablet for the treatment of cardiogenic oedema (congestive heart failure), renal oedema and hepatic oedema. It is a long-acting diuretic and should be taken orally only once a day. It is poorly absorbed orally, with a bioavailability of 10% and a peak time of about 3h. Only 2% is absorbed orally and 20% is excreted as prodrug in urine by intravenous injection. The elimination half-life after oral and intravenous injection is 2-2.5h, slightly longer than that of other sulphonamide medullary loop diuretics. Azosemide was developed by Mitsuwa Research Institute in Japan, 90% of the market is in Japan and it has been available for over 10 years.

Pharmacokinetics of Azosemide Powder :

Azosemide Powder is a raw material for the manufacture of diuretics. Azosemide Raw Materials has an inhibitory effect on  salt reabsorption and Azosemide API has a weak hypotensive effect. Azosemide Raw Materials is used as a pharmaceutical  intermediate,  Azosemide API Supplier and Manufacturer from China Pharmaceutical raw material production plants. Azosemide API Supplier  and Manufacturer from China Pharmaceutical raw material production plants.. Diuretic. It can inhibit the reabsorption of salt, but its antihypertensive effect is weak. It is used for edema of heart, liver and kidney. Use as a medical intermediate.

Clinical Application of Azosemide Powder:

Diuretic. Inhibits the reabsorption of salts, but its hypotensive effect is weak. Azosemide Raw Materials are used as pharmaceutical intermediates.

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