Cholesterol Raw material Cholesterol powder

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Product details

Cholesterol powder Usage and Synthesis.

Cholesterol is related to human tissues, bile acids and hormones, and is an indispensable and important substance for the cells of animal tissues. It is not only involved in the formation of cell membranes, but is also a precursor for the synthesis of bile acids, steroid hormones and vitamin D3.

It comes from two sources, exogenously from the diet and endogenously from the body's own synthesis. An increase in exogenous cholesterol can feedback to inhibit its endogenous synthesis.

Dietary fat aids cholesterol absorption. It is metabolized to bile acids or steroid hormones. Its absorption also depends on intake; high intake reduces the percentage absorbed; human absorption of cholesterol is less than 10% at high levels of intake, and the rest is excreted in the feces. Dietary cholesterol is absorbed into the bloodstream in the form of celiac particles.

Since it is insoluble in water, it is transported in the blood in the form bound to lipoproteins. The physiological functions of cholesterol are to make up cell membranes, nerve myelin sheaths, the brain, and to be converted to bile acids and steroid hormones.

Uses of Cholesterol powder.

(1) Involved in the formation of cell membranes.

(2) Cholesterol is the raw material for the synthesis of bile acids, vitamin D, and steroid hormones.

(3) The amount of total cholesterol in the blood serum of a normal Chinese person is about 182.5±4.3 mg%. Excessive blood cholesterol levels indicate that cholesterol metabolism may be impaired. Patients with coronary atherosclerosis tend to have high serum cholesterol levels The serum cholesterol level is often high in patients with coronary atherosclerosis.

Therefore, the measurement of serum cholesterol in clinical laboratories will help to diagnose certain diseases.

In vitro studies of Cholesterol powder.

Product method of Bulk Cholesterol powder.

Livestock brain tissue as raw material dry brain powder preparation take fresh animal brain and spinal cord (remove fat and spinal cord membrane), grinded, 40-50 ℃ drying, get dry brain powder.

Brain (pig, cow, sheep) [40-50 ℃] → dry brain powder crude cholesterol crystal preparation dry brain powder add 1.2 times the amount of acetone impregnation, constant stirring, extraction 4.5h, repeated extraction 6 times, filtration, combined extract, distillation recovery of acetone, get yellow solid matter. Add 10 times the amount of ethanol, heating reflux 1h, cholesterol ethanol solution, filtration, filtrate at 0-5 ℃ cooling, standing, precipitation of crystals, filtration, crude cholesterol crystals.

Dry brain powder [acetone] → yellow solid [ethanol] → cholesterol ethanol solution [0-5 ° C] → crude cholesterol crystals refined cholesterol preparation take crude cholesterol crystals plus 5 times the amount of ethanol, add 5% -6% sulfuric acid, heating reflux 8h, hydrolysis solution, 0-5 ° C cooling, precipitation of the crystals, filtration, get the crystals, plus ethanol wash to neutral.

Will be washed to neutral crystals plus 10 times the amount of 95% ethanol, add 3% activated carbon, heating reflux decolorization 1h, insulation filtration, filtrate 0-5 ℃ cooling crystallization, repeated 3 times, filtration, collection of crystals, pressure drying, evaporate ethanol, 70-80 ℃ vacuum drying, to get refined cholesterol.

Crude cholesterol crystals [ethanol, H2SO4] → [8h] hydrolysis solution [0-5 ℃] → crystals [ethanol, activated carbon] → [1h] refined cholesterol.

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