Supply aminophylline Raw Materials powder aminophylline

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Drug interactions of aminophylline.

1. Dilute hydrochloric acid reduces its absorption in the small intestine.

2, Acidic drugs increase its excretion, while alkaline drugs decrease it.

3、Cimetidine, erythromycin, clindamycin, lincomycin, tetracycline can reduce the clearance of aminophylline in the liver, so that its t1/2 prolongation, so the blood concentration can be higher than the normal level, easy to cause poisoning.

4、Phenytoin sodium accelerates its metabolism and reduces the blood concentration, the dosage should be increased.

5、When combined with propranolol, the bronchodilator effect of aminophylline may be inhibited.

6、Combined with lithium can accelerate the renal excretion of lithium, thus reducing the efficacy of lithium.

7, intravenous drip, should be avoided with vitamin C, corticotropin, norepinephrine, tetracycline HCl

Uses of aminophylline.

Aminophylline drug on the bronchial smooth muscle relaxation effect is the strongest, can make the bronchial dilatation, lung capacity increased, the effect is more lasting, especially for the spasm state of the bronchial effect is significant, in addition to aminophylline there is dilation of coronary arteries, increase the myocardial blood supply, enhance the role of the heart's contractile force. It is mostly used for emphysema in horses and cattle, as well as for calming pulmonary congestion (cardiac wheezing) caused by heart failure in dogs.

Pharmacological action of aminophylline.

1. Relaxation of airway smooth muscle: Aminophylline can relax airway smooth muscle and relieve bronchial spasm.

2. Immunomodulation and anti-inflammatory effect: small amount of aminophylline can inhibit the release of inflammatory transmitters from mast cells and relieve airway smooth muscle spasm; it can also inhibit the infiltration of eosinophils in bronchial tubes.

3. Enhance the contractility of respiratory muscle: prevent and control diaphragm fatigue and respiratory failure by improving respiratory function.

4. Excitement of respiratory centre: make respiration excited, enhance the depth of respiration, but the respiratory frequency does not increase.

5. Cardiotonic: acts on the heart, antagonises adenosine, prevents excessive release of adenosine, dilates coronary arteries and peripheral blood vessels, promotes myocardial contraction, and increases cardiac output.

6. Diuretic: increase renal blood flow and glomerular filtration rate, inhibit tubular reabsorption.

Product method of Bulk aminophylline Powder.

This product is the compound salt of theophylline and ethylenediamine. Put the theophylline into the mixer, stir and cool, use compressed air to spray into the mixture of newly distilled ethylenediamine and distilled water, after spraying, continue stirring for 10 minutes, to get aminophylline.

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