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The quaternary ammonium group can tend to the cationic site of phosphoacylated cholinesterase which has been deactivated by binding with organophosphorus insecticides. Its nucleophilic group can directly bind with the phosphorylated group of cholinesterase and then jointly dissociate cholinesterase, so that cholinesterase can return to its original state and become active again. The "aged" cholinesterase inhibited by organophosphorus insecticides for more than 36h had poor reactivation effect. The e effect on nicotinoid symptoms caused by organophosphus insecticides is obvious, while the E effect on central nervous system symptoms is weak.
Uses of Pralidoxime Chloride.
It can replace pralidoxime iodide and revive cholinesterase activity inhibited by acute organophosphorus insecticides to varying degrees, and save the poisoning of many organophosphate insecticides, but it has no revival effect on cholinesterase inhibited by carbamate insecticides, and has poor rescue effect on malathion, trichlorfon, dichlorvos, Dimethoate, mefluron, propylamphos and octamethion poisoning.
Pharmacological action of Pralidoxime Chloride.
Product Method of Bulk Pralidoxime Chloride.
2-methylpyridine reacted with chloromethane to obtain 2-methylpyridine chloromethane salt, and then nitrified the group with ethyl nitrite to obtain sodium phosphodoxide chloride salt, and then neutralized in ethanol solution with concentrated hydrochloric acid to pH=3-4, filtered sodium chloride, and concentrated ethanol under reduced pressure to obtain crude phosphodoxide chloride, dissolved by distilled water, decolorized by activated carbon, and recrystallized to obtain finished product.
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