Raw Materials powder Famotidine

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Famotidine powder Usage and Synthesis.

Famotidine is also called the stomach mottin serta, high serta, method, MoXian, letter d, thiazole amine, the preventive, for efficient and effective of the third generation of histamine H2 receptor blocker, receptor affinity is high, can effectively inhibit gastric acid, hydrochloric acid in gastric juice and food stimulation cause gastric acid secretion, at night can also inhibit histamine and five peptides to promote gastric stimulation such as gastrin-releasing caused by gastric acid secretion, It is suitable for gastric and duodenal ulcer, anastomotic ulcer, stress ulcer, reflux esophagitis, Zhuo - Ai syndrome and upper gastrointestinal bleeding.

Uses of Famotidine.

Histamine H2 receptor antagonist, highly selective, can inhibit gastric acid secretion for a long time. The effect is stronger, the maintenance time is longer, the safety range is wide, and there is no anti-androgen and interference with drug metabolism enzymes. Its antagonism is more than 30 times that of cimetidine and 14 times that of ranitidine. The dose used is only 1/20 of cimetidine and 1/7 of ranitidine. It is used for peptic ulcer disease, gastric and duodenal ulcer, reflux esophagitis, upper gastrointestinal bleeding, etc.

Other function of Famotidine.

Famotidine can significantly inhibit the decrease of glycoprotein content in gastric mucosa induced by stress in rats, and has a stronger inhibitory effect on the occurrence of experimental gastric ulcer or duodenal ulcer in rats than cimetidine. Continuous administration can promote healing of chronic ulcers. It can inhibit blood loss and gastric hemorrhage caused by histamine in rats. Both animal experiments and clinical double-blind comparative trials of gastrointestinal bleeding have proved that famotidine has hemostatic effect. The product also has the effect of protecting experimental gastric mucosal injury and increasing gastric mucosal blood flow. This product does not change the rate of gastric emptying, does not interfere with pancreatic function, has no teratogenic, carcinogenic, inhibiting liver drug enzymes and inhibiting male hormones.

Product method of Bulk Famotidine.

Amidinothiourea is cyclically combined with 1, 3-dichloroacetone to form 2-guanidine-4-chloromethylthiazole, which is then reacted with thiourea and then chlorpropionitrile to form 2-guanidine-4 -[((ethyl cyanothiyl) methyl] thiazole, which is then alcohololized with methanol and then aminated to famotidine.

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