Hrk supply Deoxyarbutin Raw materials powder

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Deoxyarbutin powder of Usage and Synthesis.

Deoxyarbutin is a very effective tyrosinase inhibitor and has a significant blocking effect on melanin formation in the skin. In animal skin tests, deoxyarbutin can effectively inhibit tyrosinase activity and melanin formation in the skin tissue, quickly and effectively make the skin white, and have different degrees of whitening effect on people with different skin tones, and when the use of the ingredient is stopped, the effect can still be maintained for nearly 8 weeks, and the decolorization effect can be completely reversed after 8 weeks. It does not cause permanent damage to melanocytes and is 10 times more potent than hydroquinone and 350 times more potent than arbutin. Therefore, as a new generation of cosmetic brightening and whitening active agent, it is mainly used in high-grade whitening cosmetics. The substance as an additive in cosmetics has been listed in the United States, Taiwan and other places, in the future whitening skin care products market has a very broad application. In addition, in addition to whitening, it has many other functions. As an intermediate synthetic compound, as well as synthetic liquid crystal, it can be seen.

Uses of Deoxyarbutin.

Synthesis method of Deoxyarbutin.

1. Hydroquinone direct etheration method: hydroquinone and 3, 4-dihydropyran are first dissolved in a solvent, and the solvent is slowly added at room temperature. Using Fe2(SO4)3·xH2O as catalyst, deoxyarbutin can be directly obtained by reaction in acetone. The defect of this method is that the product needs column chromatography separation and purification, which is not conducive to industrial production.

2. Using hydroquinone as raw material, Zhang Wenzheng successfully completed the etherification of tetrahydropyran through the monobenzylation of hydroquinone, and the hydroxyl group of another phenol under the catalysis of pyridine p-toluene sulfonate, and the hydroquinone protected by benzyl and tetrahydropyran with a high yield, and finally the deoxyarbutin was synthesized by catalytic hydrogenation to remove benzyl. At the same time, different adsorbents including silica gel, calcium chloride, diatomaceous earth, activated carbon and sodium carbonate are added in the dehydrogenation process, and the final selection of alkaline anhydrous sodium carbonate can not only avoid the decomposition of the product under acidic conditions, but also reduce the hydroquinone content to less than 20ppm.

Product Methods of Bulk Deoxyarbutin powder.

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