Raw Materials powder Favipiravir

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Favipiravir powder Usage and Synthesis.

Fapiravir is a nucleoside antiviral drug, the mechanism of action is not fully understood. Its target is viral RNA-dependent RNA polymerase. After oral absorption, the drug is transformed into the bioactive nucleoside triphosphate of fapiravir, which is similar in structure to purine and can compete with purine for viral RNA polymerase. The nucleoside triphosphate of Fapiravir can also be inserted into the viral RNA strand and induce fatal mutations in the virus. Therefore, from a mechanistic point of view, Fapiravir has a potential antiviral effect on various RNA viruses.

Uses of Favipiravir.

Fapiravir can be used for antiviral treatment of influenza A and B. Studies have shown that in addition to influenza virus, the drug also showed good antiviral activity against a variety of RNA viruses, such as Ebola virus, arenavirus, Bunyavirus, rabies virus and so on.

In vivo study of Favipiravir.

In mice infected with influenza virus, Favipiravir(200mg/kg/day,p.o.) protected the mice from death by influenza virus infection. In mice artificially infected with Ebola virus, Favipiravir effectively blocked virus production, achieving 95% and 99.6% antiviral efficacy, respectively, after 2 and 6 days of treatment initiation.

Product method of Bulk Favipiravir.

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