Natural Favipiravir raw Materials Powder

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Favipiravir Powder Usage and Synthesis.

Fapiravir can be used for antiviral treatment of influenza A and B. Studies have shown that in addition to influenza virus, the drug also showed good antiviral activity against a variety of RNA viruses, such as Ebola virus, arenavirus, Bunyavirus, rabies virus and so on.

Uses of Favipiravir.

Fapiravir is a nucleoside antiviral drug, the mechanism of action is not fully understood. Its target is viral RNA-dependent RNA polymerase. After oral absorption, the drug is transformed into the bioactive nucleoside triphosphate of fapiravir, which is similar in structure to purine and can compete with purine for viral RNA polymerase. The nucleoside triphosphate of Fapiravir can also be inserted into the viral RNA strand and induce fatal mutations in the virus. Therefore, from a mechanistic point of view, Fapiravir has a potential antiviral effect on various RNA viruses.

In vitro study of Favipiravir.

Favipiravir showed anti-influenza virus activity, with IC50 ranges of 0.013-0.48μg/ml, 0.039-0.089μg/ml, and 0.030-0.057μg/ml for influenza A, B and C viruses, respectively. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), concentrations of Favipiravir up to 1,000μg/ml did not show toxicity. In MDCK cells inoculated with seasonal influenza A (H1N1) virus, Favipiravir induces lethal mutations.

Product Method of Bulk Favipiravir Powder.

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