Mycophenolate Mofetil Raw material powder

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Mycophenolate Mofetil Powder Usage and Synthesis.

Morpholine ethyl mycophenolate is an immunosuppressant used in organ transplantation and is also used to treat autoimmune myasthenia gravis (MG).

Uses of Mycophenolate Mofetil.

It is mainly used to prevent allogeneic organ rejection. It is mainly used for kidney transplantation, but also for heart and liver transplantation, especially for refractory rejection after transplantation. It can be used simultaneously with cyclosporine and corticosteroids. It can also be used in rheumatoid arthritis, systemic lupus erythematosus, primary glomerulonephritis, psoriasis and other autoimmune diseases. Oral: Kidney transplantation: the initial dose is 2 to 3mg/kg per day, and the maintenance dose is 1 to 2mg/kg per day, divided into 2 to 3 times. Can be adjusted according to the condition.

Pharmacological action of Mycophenolate Mofetil.

Mycophenolate morpheate is quickly absorbed in the upper digestive tract after oral administration. The main site of absorption is in the stomach and is metabolized by plasma lipase into the pharmacologically active product enzyme phenolic acid (MPA) with an average bioavailability of 94%. The blood concentration quickly peaked 1 hour after taking the drug, and then rapidly decreased. MPA is metabolized in the liver to a stable, pharmacologically inactive glucuronide (MPAG) by gluconaldehyde acidification and excreted in the urine.

MPAG excreted in the intestine through bile enters the small intestine, where it is converted into MPA by the glucosidase of the intestinal flora, which is reabsorbed through the intestine, forming enterohepatic circulation, and a second plasma MPA peak occurs (6-12 hours after administration). About 6% of MPAG is excreted in the stool. It is activated by hydrolytic metabolism in vivo, non-competitively inhibits hypoxanthine dehydrogenase monophosphate and blocks guanine nucleotide synthesis, thus exerting its immunosuppressive effect on lymphocytes, and T lymphocytes and B lymphocytes are significantly affected by it.

Product Method of Bulk Mycophenolate Mofetil Powder.

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