Paracetamol Cichoric acid Raw Materials Powder

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Cichoric acid Powder Usage and Synthesis.

Chicoric acid is a water-soluble phenolic acid compound extracted from the dried whole herb of chicory, family Asteraceae,with anti-inflammatory, immune-enhancing, and apoptosis-inducing properties, as well as the ability to inhibit hyaluronidase and protect collagen from free radicals that can lead to degradation.

Stability of Cichoric acid.

1, pH value on the stability of chicoric acid, different pH on the stability of chicoric acid varies greatly, chicoric acid in a strong acidic environment degradation rate is lower than the weak alkaline environment.

2, the effect of temperature on the stability of high temperature leads to accelerate the degradation of chicoric acid, low temperature is conducive to the stability of chicoric acid.

3, the effect of metal ions on the stability of Na + and K + do not react with chicoric acid; however, chicoric acid reacts very rapidly with CaCl2 solution, and the mechanism of yellowing of the solution needs to be further explored. The complexity of the food system leads to the mixing of various metal ions, and other metal ions such as Ca2+ may have a greater effect on chicoric acid. When chicoric acid is applied to food, the influence of metal ions on chicoric acid in the liquid food environment or the environment after brewing should be considered, so as to avoid the reaction leading to the degradation of chicoric acid and the change of food quality.

4、Ultraviolet light on the stability of chicoric acid methanol chicoric acid is more easily affected by ultraviolet light isomerisation into endocyclic chicoric acid, and because methanol polarity is smaller than water, chicoric acid isomerisation conversion rate is higher. When chicoric acid is applied to food, it should be taken into account that the sensitivity of chicoric acid to ultraviolet rays after dissolution is high, and the contact with ultraviolet rays should be reduced in the process.

5, in the juice drink stability study low temperature storage than room temperature is more conducive to chicoric acid to maintain stability; and room temperature (25 ℃) in aqueous solution of chicoric acid after 15d basically completely decomposed, indicating that the beverage system can protect chicoric acid from degradation to a certain extent. The juice drink system itself is very complex, and the drink is labelled with 100mg of vitamin C added to the 445mL system, which has antioxidant effect and can protect chicoric acid to a certain extent, so even if it is left for 3 months, the concentration of chicoric acid is still at a high level.

6、Stability study in milk powder as a representative solid food environment, each component in the water activity is very small, isolated from the air water vapour, light environment is relatively stable, the lack of environmental factors leading to the degradation of chicoric acid, so the concentration of chicoric acid is not subject to the time and the influence of the milk powder system, in the dry and closed, room temperature conditions, storage, chicoric acid can be kept relatively stable in milk powder system. 7、In jelly, the concentration of chicoric acid is still at a high level even after 3 months. Stability

7、Stability study in jelly The jelly system itself is very stable, its water activity is very small, chicoric acid in such a relatively closed conditions of storage, isolation of oxygen and water vapour, it will be able to maintain stability for a long time. The slight fluctuation of the assay data may be caused by errors in sample handling.

Physicality of life of Cichoric acid.

L-Chicoric Acid ((-)-Chicoric acid), a dicaffeoyltartaric acid, is a potent, selective and reversible inhibitor of HIV-1 integrase with an IC50 of approximately 100 nM.L-Chicoric Acid also inhibits HIV-1 replication in tissue cultures. L-Chicoric Acid also inhibits HIV-1 replication in tissue cultures.

In vitro studies of  Bulk Cichoric acid Powder.

L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 uM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 uM and higher. L-Chicoric Acid also inhibits integration asl indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus.The EC 5o of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells.The ED 50 of L-Chicoric Acid against HIV NL4-3 control virus is 400 nM, while HIV NL4-3 passaged in the presence of 8 μM LChicoric Acid is completely resistant to the compound.L-Chicoric Acid.

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