Chlorphenamine Maleate Raw Material Powder

CAS: 113-92-8

MF: C20H23ClN2O4

Specification​: 99% min Chlorphenamine Maleate

Sample:  Chlorphenamine Maleate Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Chlorphenamine Maleate Powder Usage and Synthesis:

Chlorphenamine Maleate preparations include tablets and injections, also known as chlorpheniramine, an Antihistamine Drug, and this product plays an anti-allergic effect by antagonizing the H1 receptor. It is mainly used for rhinitis, skin and mucous membrane allergies, and relief of cold symptoms such as tearing, sneezing, and runny nose.

Chlorphenamine Maleate is used for allergic rhinitis, cold and sinusitis, and allergic skin diseases such as urticaria, allergic drug eruption or eczema, angioedema, and skin itching caused by insect bites. Production of Chlorphenamine Maleate Powder: In tetrahydrofuran solvent, add p-chlorobenzylpyridine and sodium amide, react at 20-25°C for 1 hour, then add dropwise the toluene solution of N,N-dimethylchloroethane, temperature control At 30-40°C, after the dropwise addition, react at 40-45°C for 2 hours, after the reaction, cool down to normal temperature, then add water to wash the organic phase until neutral, recover the solvent, and obtain the concentrated solution of chlorpheniramine. After vacuum distillation, chlorpheniramine was obtained. Add maleic acid in absolute ethanol, stir to dissolve, add chlorpheniramine, after the addition, stir for 30 minutes, cool down to 0～-2°C and keep warm for 2 hours, and suction filter to obtain the crude chlorpheniramine maleate .Refined with 1.5 times absolute ethanol to obtain Chlorphenamine Maleate Raw Material boutique.

Pharmacokinetics of Chlorphenamine Maleate Powder:

Chlorphenamine Maleate is an H1 receptor antagonist, and its chemical structure belongs to hydrocarbon amines. It can competitively block the histamine H1 receptor on the target cells of the allergic reaction, so that histamine cannot bind to the H1 receptor, thereby inhibiting the allergic reaction caused by it. But chlorpheniramine does not affect the metabolism of histamine, nor does it prevent the release of histamine in the body. Chlorpheniramine also has the effect of inhibiting the central nervous system and anticholinergic effect, so there are drowsiness, dry mouth, constipation, thickened sputum and dry nasal mucosa after taking the medicine. After a long period of clinical practice, it is believed that chlorpheniramine has a strong antihistamine effect, a small dosage, and small side effects.

The antihistamine effect of Chlorphenamine Maleate is stronger than that of diphenhydramine and promethazine, but the central inhibitory effect is weaker, and the anticholinergic effect is also weaker. Because of mild adverse reactions such as drowsiness, it is suitable for children and patients who need to work during the day. Chlorpheniramine still has the effect of reducing tracheal secretion and gastric acid secretion. Before the advent of a new generation of antihistamines, it was the most commonly used antihistamine in clinical practice.

Clinical Application of Chlorphenamine Maleate Powder:

Chlorphenamine Maleate Powder is used for colds and allergic diseases of the skin and mucous membranes. It can be used to treat urticaria, eczema, dermatitis, drug eruption, skin pruritus, neurodermatitis, insect bites, solar dermatitis, and can also be used for allergic dermatitis, vasomotor Rhinitis, drug and food allergies, etc. In addition to having a strong competitive effect of blocking the histamine H1 receptor on the target cells of the allergic reaction, antihistamine drugs play an anti-allergic effect by antagonizing the H1 receptor.

Like clodrimidone, brompheniramine is also an antihistamine. The production method of brompheniramine is also similar to that of chlortrimidone, except that the starting material is replaced with a bromobenzene compound. The medicine made by Chlorphenamine Maleate Powder also has anti-M choline receptor effect, so symptoms such as dry mouth, constipation, thickened phlegm, and dry nasal mucosa may appear after taking the medicine.

Drugs made from Clinical Application of Chlorphenamine Maleate Powder have obvious effects on the following diseases:

1. Rhinitis: Effective for perennial allergic rhinitis, seasonal allergic rhinitis, and vasomotor rhinitis; it can also be used for nasal congestion and sinusitis caused by respiratory infections.

2. Skin and mucous membrane allergy: mainly used for allergic diseases of skin and mucous membranes, such as angioedema, hay fever, allergic conjunctivitis, etc., and can relieve skin itching and edema caused by insect bite dermatitis and contact dermatitis .

3. Children's diseases: In addition to being effective for children's upper respiratory tract infections, it can also be used for gastrointestinal allergic diseases.

4. Drug reaction: used to prevent drug eruption and other symptoms caused by blood transfusion, infusion reaction and drug reaction.

5. Combined medication: It can be used in combination with compound aspirin or other antipyretic and analgesic drugs to treat colds and relieve cold symptoms such as tearing, sneezing, and runny nose.