Levocetirizine Raw Materials Powder

CAS: 130018-77-8

MF: C21H25ClN2O3

Specification​: 99% min Levocetirizine

Sample:  Levocetirizine Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Levocetirizine Powder Usage and Synthesis:

Levocetirizine Powder is an Antihistamine Drug raw material. Levocetirizine Raw Materials belongs to the second generation of H1 histamine receptor antagonists. Levocetirizine ((R)-Cetirizine) is a third generation peripheral H1-receptor antagonist. Levocetirizine is an antihistamine and is the R enantiomer of Cetirizine. Levocetirizine has a higher affinity for histamine H1-receptors than (S)-Cetirizine and is useful in the study of allergic rhinitis and chronic idiopathic urticaria. Levocetirizine can be used clinically for diseases or symptoms related to allergic reactions. For example, it is suitable for allergic rhinitis, including seasonal allergic rhinitis and perennial allergic rhinitis. It can improve the symptoms of allergic rhinitis, and can also It is used for skin allergic reactions such as chronic idiopathic urticaria. In short, levocetirizine hydrochloride belongs to antiallergic drugs.

Pharmacokinetics of Levocetirizine Powder:

This product is an oral selective histamine H1 receptor antagonist. There is no obvious anticholinergic and anti-serotonin effect, and the central inhibitory effect is small. Levocetirizine hydrochloride is an anti-allergic drug, which can mainly relieve the related symptoms of allergic reactions, mainly by inhibiting the related functions of histamine, which is a substance closely related to allergic reactions. Levocetirizine blocks the function of histamine through its inhibitory effect on histamine receptors and plays an anti-allergic effect. Levocetirizine has a relatively large advantage, that is, it has a relatively small inhibitory effect on the central nervous system, so it rarely causes adverse reactions of the central nervous system such as drowsiness and fatigue. In addition, there is no obvious anticholinergic and anti-serotonin effect.

Clinical Application of Levocetirizine Powder:

Levocetirizine, commonly used dosage form is tablet, capsule, dispersible tablet, oral solution. For antihistamines. For the treatment of allergy-related symptoms of the following diseases, such as seasonal allergic rhinitis, perennial allergic rhinitis, chronic idiopathic urticaria. The pharmacokinetics of levocetirizine is characterized by a linear relationship between the plasma concentration level and the administered dose, with small inter-individual differences. The absorption of levocetirizine in the human body is rapid and complete. Eating food may lead to a decrease in the absorption rate and peak plasma concentration of levocetirizine, but the overall absorption rate will not decrease. The absorption degree of levocetirizine is the same as that of Dosage is irrelevant.

Levocetirizine Raw Materials can be made into drugs with the following properties:

Levocetirizine tablets: film-coated tablets, white or off-white after the coating is removed.

Levocetirizine capsules: capsules, the contents are white or off-white granules or powder.

Levocetirizine dispersible tablets: white or off-white tablets.

Levocetirizine Oral Solution: Colorless clear viscous liquid with sweet taste.

The specifications are as follows:

Specification:

Levocetirizine tablets: 5mg.

Levocetirizine capsules: 5mg.

Levocetirizine dispersible tablets: 5mg.

Levocetirizine oral solution: 0.05%.