Pharmaceutical Promethazine Hydrochloride Powder Raw Materials CAS 58-33-3 API Factory Supply

Pharmaceutical Promethazine Hydrochloride Powder Raw Materials CAS 58-33-3 API Factory Supply

CAS:58-33-3

MF: C17H21ClN2S

MW: 320.88

EINECS:  200-375-2

Specification​: 99% min Promethazine Hydrochloride

Sample: Promethazine Hydrochloride Powder

Packaging:1kg/bag, 25kg/drum

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Portal:https://henrikang.en.made-in-china.com/

Promethazine Hydrochloride Powder Usage and Synthesis.

Promethazine Hydrochloride Powder, also known as Finagan, is a commonly used phenothiazine antihistamine in clinical practice, and although clinical reports of its adverse effects are not uncommon, it is still commonly used in primary hospitals due to its clear action and low price.

Promethazine Hydrochloride Raw Promethazine Hydrochloride Raw is the earliest tricyclic antihistamine with the structure of phenothiazine, which has the effect of cough suppressant. 

Promethazine HCL Powder is able to competitively block the histamine H1 receptor and produce antihistamine, and reduce the capillary dilatation and permeability caused by antihistamine. Therefore, Promethazine HCL Powder is able to calm coughs caused by irritation of the airways.

Uses and functions of Promethazine Hydrochloride Powder.

• 1. Allergy of skin and mucous membranes: for long-term, seasonal allergic rhinitis, vasodilatory rhinitis, allergic conjunctivitis caused by contact with allergens or food, urticaria, angioneurotic oedema, allergic reaction to blood or plasma products, skin scratching disease. If necessary, it can be combined with epinephrine as an adjuvant to this drug.
• 2. Motion sickness: prevention and treatment of motion sickness, seasickness, airsickness.
• 
• 3. Sedation, hypnosis: for preoperative, postoperative and obstetrics. In addition, it can also be used to reduce the fear of adults and children in a light sleep state.
• 4. Treatment of nausea and vomiting: it is applicable to nausea and vomiting after some anaesthesia and surgery, and is also used to prevent and control radiopathic or pharmacogenetic nausea and vomiting.
• 5. Post-operative pain: it can be used in combination with painkillers as an auxiliary medicine.

Pharmacological Effects of Promethazine Hydrochloride Powder.

Isoprinosine is a phenothiazine antihistamine, which can also be used for antiemetic, antimotion sickness and sedative-hypnotic.

1. 1,Antihistamine effect: competes with histamine released from tissues for H1 receptors, antagonises the contraction or clonus of the gastrointestinal tract, the trachea, the bronchial tubes, or the fine bronchial smooth muscle, and relieves spasmodic and congestive effects of histamine on the bronchial smooth muscle.

1. 2, antiemetic effect: may be related to the inhibition of the medulla oblongata emetic chemoreceptor area.
2. 3, Anti-motion sickness: may be through the central anticholinergic properties, the role of the vestibular and vomiting centre and the medullary receptors in the midbrain, mainly blocking the excitation of the vestibular nucleus area cholinergic synaptic labyrinthine impulses.
3. 4. Sedative-hypnotic effect: probably due to indirectly reducing the stress of the brainstem reticularis superior activation system.

Production method of Promethazine Hydrochloride Powder.

Suitable for all kinds of allergic diseases and vomiting during pregnancy. 

Use Indications: 

Can competitively block the histamine Hl receptor and produce antihistamine, can fight against histamine-induced capillary dilatation, reduce its permeability, alleviate bronchial smooth muscle contraction caused by wheezing, more than the effect of benzylhydramine hydrochloride is strong and long-lasting.