ACP-196 Acalabrutinib Raw Material Powder

Product Name: ACP-196 Acalabrutinib Raw Material Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Specification​: 99% min ACP-196 Acalabrutinib

Test Method: HPLC

CAS: 1420477-60-6

MF: C26H23N7O2

Sample:  ACP-196 Acalabrutinib Powder

Keywords: ACP-196 Powder,Acalabrutinib Powder,ACP-196 Raw Material Powder

ACP-196 Acalabrutinib Usage and Synthesis:
ACP-196 Acalabrutinib Powder is an experimental cancer drug,Acalabrutinib Raw Material Powder is a second-generation small molecule Bruton's tyrosine kinase inhibitor.Wholesale ACP-196 Acalabrutinib Raw Material Powder from China Manufacturer And Supplier Manufacturer.ACP-196 Acalabrutinib is a choice A second-generation BTK inhibitor that inhibits the activation of the primary antibody signaling pathway on the surface of B cells. It has excellent target specificity and is 323-, 94-, 19-, 9-fold more selective for BTK than other TEC kinase family members such as ITK, TXK, BMK and TEC. No activity on EGFR. ACP-196 Powder, an experimental anticancer drug, is a selective Bruton's tyrosine kinase (BTK) inhibitor. Acalabrutinib Powder is an experimental anticancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor.

Pharmacokinetics of ACP-196 Acalabrutinib :
Acalabrutinib is a second-generation small molecule Bruton's tyrosine kinase inhibitor. ACP-196 Raw Material Powder and its metabolite ACP-5862 form a covalent bond with the 481st cysteine ​​residue in the active site of BTK, which inhibits the activity of BTK enzyme; and BTK acts as a B cell antigen receptor and cytokine Signaling molecules for receptor channels. In B cells, the activation of BTK signaling is a channel signal necessary for B cell proliferation, transport, chemotaxis and adhesion. Acatinib and its metabolites selectively block the BTK pathway without destroying other molecular pathways important to platelet and immune function, thereby avoiding or reducing the occurrence of adverse reactions related to cancer therapy.

Clinical Application of ACP-196 Acalabrutinib:
English name: Acalabrutinib
English synonyms: ACP196;ACP-196;acalabrutinib;Benzamide,4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1 ,5-a]pyrazin-1-yl]-N-2-pyridinyl-;ACP196,Acalabrutinib;EOS-60753;(S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2 -yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
CAS number: 1420477-60-6
Molecular formula: C26H23N7O2
Molecular weight: 465.51
EINECS Number: 814-272-0