Antineoplastic Adriamycin CAS 23214-92-8 Raw Materials Powder

CAS: 23214-92-8 

MF: C27H29NO11

Specification​: 99% min Adriamycin Powder

Sample: Adriamycin Powder

Brand: Henrikang

Appearance: White Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

MADE IN CHINA Store:https://henrikang.en.made-in-china.com/

Adriamycin Powder Usage and Synthesis 

Adriamycin, also known as 14-hydroxynordimycin, 14-hydroxirubicin, doxorubicin, adriamycin, adriamycin, hydroxyerythromycin, is an anthracycline anti-tumor antibiotic, a cell cycle non-specific drug (CCNSA), sensitive to S and M phases. The hydrochloride is orange-red needle-like crystals. Melting point 204～205℃. Freely soluble in water, ethanol, methanol. Stable in aqueous solution, unchanged at 5℃ for 1 month, but unstable at higher temperature or in acidic solution or alkaline solution. Acidic aqueous solution is orange-yellow, neutral is orange-red, alkaline (pH>9) is purple-blue. Insoluble in acetone, benzene, petroleum ether, ether, chloroform.

Adriamycin Powder belongs to the anthracycline group of antitumor drugs, which is structurally similar to erythromycin and has strong anticancer Adriamycin Raw Materials is a broad-spectrum antibiotic that belongs to the tetracycline group of drugs. It can be used to treat a variety of infections, such as respiratory tract infections, urinary tract infections, and skin infections. Adriamycin CAS 23214-92-8 kills bacteria by inhibiting their protein synthesis.
However, due to its broad-spectrum nature, improper use may lead to the development of bacterial drug However, due to its broad-spectrum nature, improper use may lead to the development of bacterial drug resistance.

It is an antitumor antibiotic isolated from cultures of Actinomyces spp. Its mechanism of action is similar to that of erythromycin, with a broader antitumor spectrum and a higher therapeutic index. It is used clinically in the treatment of acute and chronic lymphocytic leukemia and solid tumor leukemia, lymphoma, breast cancer, ovarian cancer,, soft tissue sarcoma, osteogenic sarcoma, rhabdomyosarcoma, Ewing's sarcoma, nephroblastoma, neuroblastoma, gastric cancer, pancreatic cancer, hepatocellular carcinoma, prostate cancer, head and neck squamous carcinoma, testicular cancer, lung cancer, bladder cancer, medullary thyroid cancer and sarcoma. The toxicity of this product includes bone marrow suppression, gastrointestinal reactions and cardiotoxicity.

Application/Function of Adriamycin Powder .

It is mainly used for acute or chronic leukemia, Hodgkin's and non-Hodgkin's lymphoma, malignant lymphoma, those who are resistant to erythromycin are still sensitive to Adriamycin, it is also effective in Ewing tumor, osteosarcoma, soft tissue tumor, lung cancer, choriocapillaris, breast cancer, bladder cancer, thyroid cancer and soft tissue tumor. Combination with cytarabine, vincristine and fluorouracil can increase its efficacy. Tumor cells can develop resistance to adriamycin.
 

Resistant cells have reduced permeability of cell membranes compared with sensitive cells, and the cells take up less adriamycin and have active excretion of adriamycin. Cells resistant to erythromycin are cross-resistant to adriamycin.
 

It is used clinically in the treatment of acute and chronic lymphocytic leukemia and solid tumors. Adverse effects include myelosuppression and cardiotoxicity.

Production method of Adriamycin Powder .

Adriamycin is an anthracyclic antitumor drug, similar in structure to erythromycin, differing only in the side chain 14 carbon atom with a hydroxyl substitution, containing both lipid-soluble anthracyclic ligands and water-soluble erythromycin, with acidic phenolic hydroxyl group and basic amino group, so it has strong anticancer pharmacological activity. Adriamycin can be obtained from Streptomyces cultures (Str. pe-ucetiusvar. caesius).

Due to the quinone-hydroquinone structure on the ligand of the anthraquinone ring in the molecule, which has the ability to accept electrons and provide neutrons, it inserts between adjacent base pairs of DNA, generating reactive free radicals, causing DNA double-stranded helix deconvolution and DNA strand breakage, inhibiting the template activity of nucleic acids, interfering with the transcription process, and preventing mRNA synthesis. It may also cause cell membrane rupture and present cytotoxic effects, and is a cell cycle non-specific drug.

It has the function of forming superoxide radicals and has a special effect of destroying cell membrane structure and function. It has an effect on all phases of cells, but it is most sensitive to the early S phase, followed by M phase, and least sensitive to G1 phase, and has a delayed effect on G1, S and G2 phases. However, the maximum cytotoxic effect occurred in S phase and was more sensitive to early S phase and M phase cells. Adriamycin can cause chromosomal aberrations in cells and increase the rate of chromosome exchange.

Drug Interactions.

1. Cross-resistance with erythromycin, vincristine and actinomycin D.

2. Synergistic effects with cyclophosphamide, fluorouracil, methotrexate, chlortalidomide, cisplatin and nitrosoureas.

3. Use live virus vaccination with caution during drug administration.

4. Combination with azathioprine or mercaptopurine may increase adriamycin hepatotoxicity.